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通过焦磷酸亚锡进行锝-99m标记:在博来霉素和红细胞中的应用。

Technetium-99m labeling by means of stannous pyrophosphate: application to bleomycin and red blood cells.

作者信息

Bardy A, Douyé H, Gobin R, Beydon J, de Tovar G, Pannecière C, Hégésippe M

出版信息

J Nucl Med. 1975 May;16(5):435-7.

PMID:53279
Abstract

A new technique of technetium labeling using stannous pyrophosphate instead of stannous chloride as reducing agent for pertechnetate has been applied to red blood cells and bleomycin. Results are so encouraging that this technique could be extended to other compounds capable of forming stable complexes with reduced technetium. No saline washes of red cells are necessary before or after the addition of pertechnetate. No purification step is performed after labeling of bleomycin.

摘要

一种使用焦磷酸亚锡而非氯化亚锡作为高锝酸盐还原剂的锝标记新技术已应用于红细胞和博来霉素。结果非常令人鼓舞,以至于该技术可扩展到其他能够与还原态锝形成稳定络合物的化合物。在添加高锝酸盐之前或之后,无需对红细胞进行盐水洗涤。博来霉素标记后不进行纯化步骤。

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Technetium-99m labeling by means of stannous pyrophosphate: application to bleomycin and red blood cells.通过焦磷酸亚锡进行锝-99m标记:在博来霉素和红细胞中的应用。
J Nucl Med. 1975 May;16(5):435-7.
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引用本文的文献

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Modifying effect of commercially available stannous pyrophosphate (PYRO-Sn) on the tissue affinity of 99mTc pertechnetate.
Eur J Nucl Med. 1980;5(1):45-7. doi: 10.1007/BF00261206.
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Labeling of human lymphocytes with 99mTc by means of stannous pyrophosphate. Scintigraphic applications.通过焦磷酸亚锡用99mTc标记人淋巴细胞。闪烁扫描应用。
Eur J Nucl Med. 1982;7(9):397-404. doi: 10.1007/BF00256818.
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A comment on "Kinetics of 99mTc-tin-methylene diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism".
Calcif Tissue Int. 1983;35(2):261. doi: 10.1007/BF02405041.
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In vitro labeling of human polymorphonuclear leukocytes with 99mTc.
Eur J Nucl Med. 1984;9(8):366-9. doi: 10.1007/BF00252872.
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A radionuclide study on the effectiveness of drainage after elective cholecystectomy.择期胆囊切除术后引流效果的放射性核素研究。
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Br Heart J. 1986 Mar;55(3):274-82. doi: 10.1136/hrt.55.3.274.
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Modeling sickle cell vasoocclusion in the rat leg: quantification of trapped sickle cells and correlation with 31P metabolic and 1H magnetic resonance imaging changes.
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Use of stannous methylene diphosphonate for labelling red blood cells with 99m Tc.
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The first case of a complete deficiency of diphosphoglycerate mutase in human erythrocytes.人类红细胞中磷酸甘油酸变位酶完全缺乏的首例病例。
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