他莫昔芬（ICI 46,474）对植入前晚期小鼠囊胚表面被膜的影响。
An effect of Tamoxifen (I.C.I. 46,474) on the surface coat of the late preimplantation mouse blastocyst.
作者信息
Bloxham P A, Pugh D M, Sharma S C
出版信息
J Reprod Fertil. 1975 Oct;45(1):181-3. doi: 10.1530/jrf.0.0450181.
PMID:53283
Abstract
The oral adminitration of Tamoxifen on Days 2,3 and 4 after mating, or on Day 2 only, was found to prevent the oestrogen-dependent surface-coat change of the late preimplantation blastocyst in the mouse. It is suggested that his is an antioestrogenic manifestation and that ist is, at least in part, responsible for the drug's known antifertility effect.
摘要
在交配后第2、3和4天或仅在第2天口服他莫昔芬，可防止小鼠植入前晚期囊胚依赖雌激素的表面被膜变化。提示这是一种抗雌激素表现，并且至少部分地是该药物已知抗生育作用的原因。
Zotero 插件