鼠伤寒沙门氏菌提取物合成甲硫氨酸的过程。
Methionine synthesis by extracts of Salmonella typhimurium.
作者信息
Cauthen S E, Foster M A, Woods D D
出版信息
Biochem J. 1966 Feb;98(2):630-5. doi: 10.1042/bj0980630.
Abstract
- Following the genetic studies by Smith (1961) and Smith & Childs (1963) with methionine auxotrophs of Salmonella typhimurium, methionine formation from homocysteine has been investigated with cell-free extracts of this organism. 2. As found with Escherichia coli (Woods, Foster & Guest, 1964), methyl groups are formed by an N(5)N(10)-methylenetetrahydrofolate reductase. They are then transferred to homocysteine by either a simple N(5)-methyltetrahydropteroyl-triglutamate-homocysteine methyltransferase or alternatively a cobalamin-dependent N(5)-methyltetrahydrofolate-homocysteine methyltransferase. 3. S. typhimurium differs from E. coli in being able to synthesize significant amounts of cobalamin.
摘要
- 继史密斯（1961年）以及史密斯与蔡尔兹（1963年）对鼠伤寒沙门氏菌蛋氨酸营养缺陷型进行遗传学研究之后，人们利用该生物体的无细胞提取物对同型半胱氨酸生成蛋氨酸的过程展开了研究。2. 正如在大肠杆菌中所发现的那样（伍兹、福斯特与格斯特，1964年），甲基由N(5)N(10)-亚甲基四氢叶酸还原酶生成。然后，它们通过一种简单的N(5)-甲基四氢蝶酰三谷氨酸-同型半胱氨酸甲基转移酶或者一种钴胺素依赖性N(5)-甲基四氢叶酸-同型半胱氨酸甲基转移酶转移至同型半胱氨酸。3. 鼠伤寒沙门氏菌与大肠杆菌的不同之处在于它能够合成大量的钴胺素。
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