鼠伤寒沙门氏菌中的新型甲硫氨酸结构基因。
New methionine structural gene in Salmonella typhimurium.
作者信息
Childs J D, Smith D A
出版信息
J Bacteriol. 1969 Oct;100(1):377-82. doi: 10.1128/jb.100.1.377-382.1969.
Abstract
Eight metH mutants in Salmonella typhimurium with closely linked sites of mutation which could grow only on methionine were isolated from a metE mutant deficient in N(5)-methyltetrahydropteroyltriglutamate-homocysteine transmethylase; their deficiency in cobalamin-dependent N(5)-methyltetrahydrofolate-homocysteine transmethylase was supported by the results of enzyme studies of one of them. Cotransduction of metH and metA (homoserine O-transsuccinylase) mutants was obtained, thus revealing linkage between a second pair of the six known methionine structural genes. One metH mutant clearly differed from the rest in that it reverted at a higher frequency, was temperature sensitive, complemented all other metH mutants, and was located farthest from the metA gene.
摘要
从缺乏N(5)-甲基四氢蝶酰三谷氨酸-同型半胱氨酸转甲基酶的metE突变体中分离出8个鼠伤寒沙门氏菌的metH突变体，这些突变体的突变位点紧密连锁，且只能在甲硫氨酸上生长；对其中一个突变体的酶学研究结果证实了它们缺乏钴胺素依赖性N(5)-甲基四氢叶酸-同型半胱氨酸转甲基酶。获得了metH和metA（高丝氨酸O-转琥珀酰酶）突变体的共转导，从而揭示了六对已知甲硫氨酸结构基因中的第二对之间的连锁关系。一个metH突变体与其他突变体明显不同，它回复突变频率更高，对温度敏感，能互补所有其他metH突变体，且位于离metA基因最远的位置。
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