Degowin R L, Eppes R B, Carson P E, Powell R D
Bull World Health Organ. 1966;34(5):671-81.
In view of the problems caused by the chloroquine-resistance of some strains of Plasmodium falciparum, the authors have investigated the effectiveness of diaphenylsulfone against two such resistant strains, from Malaya and Viet-Nam. They found that diaphenylsulfone given during acute attacks of malaria had a blood schizontocidal activity against the Malayan resistant strain but was not rapidly effective in terminating acute attacks in non-immune persons, and that, when the drug was given prophylactically in relatively small doses, it was substantially effective in preventing patency of mosquito-induced infection with the same strain. The protective effect of diaphenylsulfone is that of a clinical prophylactic or suppressive drug; it does not appear to be a true causal prophylactic. It was also found that the protective effect is vitiated by the concurrent administration of paraaminobenzoic acid.These studies indicate a need for further assessment of the antimalarial value of sulfones and sulfonamides, both alone and in combination with other drugs, for prevention and cure.
鉴于某些恶性疟原虫菌株出现氯喹抗性所引起的问题，作者研究了二苯砜对来自马来亚和越南的两种此类抗性菌株的有效性。他们发现，在疟疾急性发作期间给予二苯砜，对马来亚抗性菌株具有血液裂殖体杀灭活性，但对非免疫人群的急性发作终止效果不迅速，而且，当以相对小的剂量预防性给药时，它对预防同一菌株的蚊虫传播感染的显性感染相当有效。二苯砜的保护作用是临床预防或抑制药物的作用；它似乎不是真正的病因性预防药物。还发现，同时给予对氨基苯甲酸会削弱其保护作用。这些研究表明需要进一步评估砜类和磺胺类药物单独以及与其他药物联合用于预防和治疗的抗疟价值。
