新型抗疟化合物的临床试验。
Clinical testing of new antimalarial compounds.
作者信息
Canfield C J, Rozman R S
出版信息
Bull World Health Organ. 1974;50(3-4):203-12.
Abstract
More than 200 000 chemical compounds have been screened for antimalarial activity over the past 10 years by the US Army Antimalarial Drug Development Program. By means of extensive animal testing, 26 of these compounds were selected for clinical study in human subjects volunteering for such trials. Of these, 7 have received complete clinical trials and are in various stages of field evaluation, 4 are currently undergoing clinical trial, and 2 are still awaiting testing in volunteer subjects. Thus far, 2 compounds (WR 33 063 and WR 30 090) have demonstrated greater activity against drug-resistant Plasmodium falciparum than any other known drug. Several other compounds presently being tested in human subjects are even more potent.
摘要
在过去十年里，美国陆军抗疟药物研发项目已对20多万种化合物进行了抗疟活性筛选。通过广泛的动物试验，从这些化合物中挑选出26种用于自愿参与此类试验的人体临床研究。其中，7种已完成临床试验，处于不同阶段的现场评估；4种目前正在进行临床试验；2种仍在等待在志愿者身上进行测试。到目前为止，有2种化合物（WR 33 063和WR 30 090）对耐药恶性疟原虫的活性比任何其他已知药物都更强。目前正在人体试验的其他几种化合物效力甚至更高。
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