红细胞吞噬作用对巨噬细胞与沙门氏菌体外相互作用的影响。
The influence of erythrophagocytosis on the interaction of macrophages and salmonella in vitro.
作者信息
Gill F A, Kaye D, Hook E W
出版信息
J Exp Med. 1966 Aug 1;124(2):173-83. doi: 10.1084/jem.124.2.173.
Abstract
Phagocytosis and killing of Salmonella typhimurium by mouse peritoneal macrophages was inhibited when the bacteria and antibody-coated homologous erythrocytes or heterologous erythrocytes were simultaneously exposed to macrophages in vitro. No inhibition of phagocytosis or killing was observed in experiments employing uncoated or disrupted antibody-coated homologous erythrocytes. Degradation of S. typhimurium as measured by the loss of fluorescence from intracellular salmonella coated with fluorescein-labeled antibody was inhibited in macrophages which had previously ingested antibody-coated homologous erythrocytes. Anti-mouse-erythrocyte serum was found to have a cytotoxic action on mouse macrophages. However, the viability of macrophages was not altered by phagocytosis of antibody-coated homologous erythrocytes or uncoated heterologous erythrocytes.
摘要
当在体外将细菌与抗体包被的同源红细胞或异源红细胞同时暴露于小鼠腹腔巨噬细胞时，巨噬细胞对鼠伤寒沙门氏菌的吞噬作用和杀伤作用受到抑制。在使用未包被或破损的抗体包被同源红细胞的实验中，未观察到吞噬作用或杀伤作用受到抑制。用荧光素标记抗体包被的细胞内沙门氏菌荧光损失来衡量的鼠伤寒沙门氏菌降解，在先前摄取了抗体包被同源红细胞的巨噬细胞中受到抑制。发现抗小鼠红细胞血清对小鼠巨噬细胞有细胞毒性作用。然而，抗体包被同源红细胞或未包被异源红细胞的吞噬作用并未改变巨噬细胞的活力。
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本文引用的文献
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