庆大霉素与青霉素联合用于实验性小鼠李斯特菌病的协同作用评估。
Evaluation of gentamicin and penicillin as a synergistic combination in experimental murine listeriosis.
作者信息
Edmiston C E, Gordon R C
出版信息
Antimicrob Agents Chemother. 1979 Dec;16(6):862-3. doi: 10.1128/AAC.16.6.862.
Abstract
The administration of a combination of penicillin and gentamicin to mice given an intraperitoneal challenge of a highly pathogenic strain of Listeria monocytogenes resulted in increased survival as compared with groups receiving penicillin alone or gentamicin alone or a control group that received no antibiotic. The median survival of animals that eventually died was no longer than in groups receiving single antibiotics and suggests that additional studies should be carried out to further investigate the possibility of synergism in animal models.
摘要
对腹腔注射高致病性单核细胞增生李斯特菌菌株的小鼠给予青霉素和庆大霉素联合用药，与单独接受青霉素、单独接受庆大霉素的组或未接受抗生素的对照组相比，存活率有所提高。最终死亡动物的中位生存期不超过接受单一抗生素治疗的组，这表明应开展进一步研究，以在动物模型中进一步探究协同作用的可能性。
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