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硫丹中毒与慢性脑综合征

Endosulfan poisoning and chronic brain syndrome.

作者信息

Aleksandrowicz D R

出版信息

Arch Toxicol. 1979 Oct;43(1):65-8. doi: 10.1007/BF00695875.

DOI:10.1007/BF00695875
PMID:533363
Abstract

The author describes a case of acute poisoning by endosulfan (a chlorinated hydrocarbon insecticide) in an industrial worker, with residual psychiatric syndrome. The acute phase was manifested by repeated convulsions and impaired consciousness. After recovery the patient became disoriented and agitated. The residual phase, 2 years after initial hospitalization, was manifested by cognitive and emotional deterioration, severe impairment of memory and inability to perform any but the simplest tasks. Psychological tests revealed gross impairment of visual-motor coordination. The differential diagnosis of chronic brain syndrome requires accurate history and milder cases of endosulfan poisoning may easily be overlooked or misdiagnosed.

摘要

作者描述了一例工业工人因硫丹(一种氯代烃杀虫剂)急性中毒并伴有残留精神综合征的病例。急性期表现为反复惊厥和意识障碍。康复后,患者出现定向障碍和烦躁不安。初始住院两年后的残留期表现为认知和情感衰退、记忆力严重受损以及除最基本任务外无法完成任何任务。心理测试显示视觉运动协调严重受损。慢性脑综合征的鉴别诊断需要准确的病史,硫丹中毒较轻的病例可能很容易被忽视或误诊。

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本文引用的文献

1
Forensic medical and forensic chemical study of acute lethal poisinnins with thiodan.关于含硫丹的急性致死性毒物的法医学与法医化学研究
Folia Med (Plovdiv). 1974;16(5-6):325-9.
2
Endosulfan-induced neurotoxicity in rats and mice.硫丹对大鼠和小鼠的神经毒性。
Bull Environ Contam Toxicol. 1976 Jun;15(6):708-13. doi: 10.1007/BF01685621.
农用化学品、α-突触核蛋白与帕金森病。
Mol Neurobiol. 2013 Apr;47(2):598-612. doi: 10.1007/s12035-012-8333-2. Epub 2012 Aug 30.
4
Effect of chronic endosulfan treatment on pharmacological actions on diazepam in rats.慢性硫丹处理对大鼠地西泮药理作用的影响。
Bull Environ Contam Toxicol. 1993 Jul;51(1):18-23. doi: 10.1007/BF00200995.
5
Alteration in the tranquilizing potency of chlorpromazine in rats exposed chronically to the insecticide, endosulfan.长期接触杀虫剂硫丹的大鼠中氯丙嗪镇静效力的改变。
Bull Environ Contam Toxicol. 1994 Nov;53(5):655-62. doi: 10.1007/BF00196936.