Zykov M P, Geser A, Egsmose T, Godovannyi B A, Donets I, Ang'awa J A, Patel R I, Blocher C, Poti S J
Bull World Health Organ. 1966;35(4):581-92.
Takahashi reported in 1962 that his kaolin-agglutination test (KAT), using the phosphatide fraction of Mycobacterium tuberculosis as antigen, was capable of detecting specific antibodies in sera from patients with pulmonary tuberculosis, and that the test could differentiate between active and inactive disease.The present study was designed to investigate the diagnostic efficiency of the KAT under conditions that prevail in Africa. Blood specimens were obtained from various categories of people, ranging from presumably healthy tuberculin-negative persons to patients with far-advanced pulmonary tuberculosis, and these specimens were submitted "blindly" for serological testing.The results showed that the KAT was less sensitive and also less specific in Kenya than it had been found in Japan by Takahashi. Some reasons for this discrepancy are discussed, but no final conclusion is reached.
高桥在1962年报告称，他的高岭土凝集试验（KAT），使用结核分枝杆菌的磷脂部分作为抗原，能够检测肺结核患者血清中的特异性抗体，并且该试验可以区分活动性和非活动性疾病。本研究旨在调查在非洲普遍存在的条件下KAT的诊断效率。从各类人群中采集血液样本，从推测健康的结核菌素阴性者到晚期肺结核患者，这些样本被“盲目”提交进行血清学检测。结果表明，KAT在肯尼亚的敏感性和特异性均低于高桥在日本所发现的。讨论了这种差异的一些原因，但未得出最终结论。
