腺苷对硫胺素生物合成的去抑制作用——一种研究该生物合成途径的工具。
The de-repression of thiamine biosynthesis by adenosine a tool for investigating this biosynthetic pathway.
作者信息
Newell P C, Tucker R G
出版信息
Biochem J. 1966 Aug;100(2):512-6. doi: 10.1042/bj1000512.
Abstract
- Growth of Salmonella typhimurium LT2 in the presence of adenosine was shown to cause enormous synthesis of thiamine in washed-cell suspensions. 2. Evidence that this was due to de-repression and not an accumulation of precursors was obtained by using a mutant blocked in the biosynthesis of the thiazole moiety, which showed a similarly large synthesis of the pyrimidine of thiamine. 3. The specific requirements for a source of energy, nitrogen and sulphur were investigated, and indicated new synthesis in this system.
摘要
- 鼠伤寒沙门氏菌LT2在腺苷存在的情况下生长，结果表明，在洗涤过的细胞悬液中会大量合成硫胺素。2. 通过使用在噻唑部分生物合成中受阻的突变体，获得了证据，表明这是由于去阻遏而非前体积累所致，该突变体显示出硫胺素嘧啶部分同样大量的合成。3. 研究了对能量、氮和硫来源的特定需求，并表明该系统中有新的合成过程。
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本文引用的文献
1
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Biochem J. 1938 Sep;32(9):1516-20. doi: 10.1042/bj0321516.
2
Intermediates of Vitamin B(1) and Growth of Phycomyces.维生素B1中间体与毛霉的生长
Proc Natl Acad Sci U S A. 1937 Sep;23(9):499-502. doi: 10.1073/pnas.23.9.499.
3
Mutants of Escherichia coli requiring methionine or vitamin B12.需要甲硫氨酸或维生素B12的大肠杆菌突变体。
J Bacteriol. 1950 Jul;60(1):17-28. doi: 10.1128/jb.60.1.17-28.1950.
4
Incorporation of formate-C 14 into the pyrimidine moiety of thiamine.将甲酸 -C¹⁴ 掺入硫胺素的嘧啶部分。
J Bacteriol. 1959 Oct;78(4):545-9. doi: 10.1128/jb.78.4.545-549.1959.
5
Enzymic synthesis of thiamine.硫胺素的酶促合成
Biochim Biophys Acta. 1959 Jul;34:277-9. doi: 10.1016/0006-3002(59)90270-7.
6
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7
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J Vitaminol (Kyoto). 1964 Jun 10;10:105-10. doi: 10.5925/jnsv1954.10.105.
8
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