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Selective inactivation of the glutamine binding site of Escherichia coli carbamyl phosphate synthetase by 2-amino-4-oxo-5-chloropentanoic acid.

作者信息

Khedouri E, Anderson P M, Meister A

出版信息

Biochemistry. 1966 Nov;5(11):3552-7. doi: 10.1021/bi00875a024.

DOI:10.1021/bi00875a024
PMID:5339592
Abstract
摘要

相似文献

1
Selective inactivation of the glutamine binding site of Escherichia coli carbamyl phosphate synthetase by 2-amino-4-oxo-5-chloropentanoic acid.2-氨基-4-氧代-5-氯戊酸对大肠杆菌氨甲酰磷酸合成酶谷氨酰胺结合位点的选择性失活作用
Biochemistry. 1966 Nov;5(11):3552-7. doi: 10.1021/bi00875a024.
2
Interaction of Escherichia coli carbamyl phosphate synthetase with glutamine.大肠杆菌氨甲酰磷酸合成酶与谷氨酰胺的相互作用。
Biochemistry. 1973 May 22;12(11):2061-6. doi: 10.1021/bi00735a006.
3
Inhibition by dithiothreitol of the utilization of glutamine by carbamyl phosphate synthetase. Evidence for formation of hydrogen peroxide.二硫苏糖醇对氨甲酰磷酸合成酶利用谷氨酰胺的抑制作用。过氧化氢形成的证据。
J Biol Chem. 1974 Mar 25;249(6):1915-21.
4
Identification of a reactive cysteine residue at the glutamine binding site of carbamyl phosphate synthetase.在氨甲酰磷酸合成酶谷氨酰胺结合位点鉴定出一个反应性半胱氨酸残基。
J Biol Chem. 1972 Oct 10;247(19):6119-27.
5
Effect of potassium cyanate on the catalytic activities of carbamyl phosphate synthetase.氰酸钾对氨甲酰磷酸合成酶催化活性的影响。
Biochem Biophys Res Commun. 1973 Nov 1;55(1):246-52. doi: 10.1016/s0006-291x(73)80086-5.
6
Reversible reaction of cyanate with a reactive sulfhydryl group at the glutamine binding site of carbamyl phosphate synthetase.氰酸盐与氨甲酰磷酸合成酶谷氨酰胺结合位点处的活性巯基发生的可逆反应。
Biochemistry. 1975 Aug 12;14(16):3688-94. doi: 10.1021/bi00687a027.
7
Carbamyl phosphate and acetyl phosphate synthesis in Escherichia coli: analysis of associated enzyme activities by an antibody to acetokinase.大肠杆菌中氨甲酰磷酸和乙酰磷酸的合成：用抗乙酰激酶抗体分析相关酶活性
J Bacteriol. 1966 Jun;91(6):2286-90. doi: 10.1128/jb.91.6.2286-2290.1966.
8
Functional arginyl residues as ATP binding sites of glutamine synthetase and carbamyl phosphate synthetase.作为谷氨酰胺合成酶和氨甲酰磷酸合成酶ATP结合位点的功能性精氨酰残基。
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2616-20. doi: 10.1073/pnas.72.7.2616.
9
Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits.谷氨酰胺依赖性氨甲酰磷酸合成酶单体可逆解离为具有催化活性的重链和轻链亚基。
J Biol Chem. 1974 Jan 25;249(2):492-9.
10
Self-association and allosteric properties of glutamine-dependent carbamyl phosphate synthetase. Reversible dissociation to monomeric species.谷氨酰胺依赖性氨甲酰磷酸合成酶的自缔合和别构性质。可逆解离为单体形式。
J Biol Chem. 1974 Jan 25;249(2):482-9.

引用本文的文献

1
Regulation of carbamoylphosphate synthesis in Escherichia coli: an amazing metabolite at the crossroad of arginine and pyrimidine biosynthesis.大肠杆菌中氨甲酰磷酸合成的调控：精氨酸和嘧啶生物合成交汇点处的神奇代谢物。
Amino Acids. 2018 Dec;50(12):1647-1661. doi: 10.1007/s00726-018-2654-z. Epub 2018 Sep 20.
2
Controlled proteolysis of the multifunctional protein that initiates pyrimidine biosynthesis in mammalian cells: evidence for discrete structural domains.对启动哺乳动物细胞嘧啶生物合成的多功能蛋白质进行的可控蛋白水解：离散结构域的证据。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6647-51. doi: 10.1073/pnas.78.11.6647.
3
Reversible dissociation of carbamyl phosphate synthetase into a regulated synthesis subunit and a subunit required for glutamine utilization.
氨甲酰磷酸合成酶可逆解离为一个受调控的合成亚基和一个谷氨酰胺利用所需的亚基。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2599-603. doi: 10.1073/pnas.68.10.2599.
4
Observations on the pH dependence of the glutaminase activity of a glutamine amidotransferase, carbamylphosphate synthetase.谷氨酰胺酰胺转移酶（氨甲酰磷酸合成酶）谷氨酰胺酶活性的pH依赖性观察
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2717-21. doi: 10.1073/pnas.70.10.2717.
5
Glutamine-binding subunit of glutamate synthase and partial reactions catalyzed by this glutamine amidotransferase.谷氨酸合酶的谷氨酰胺结合亚基以及该谷氨酰胺氨基转移酶催化的部分反应。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4607-11. doi: 10.1073/pnas.71.11.4607.
6
Physiology and genetics of carbamoylphosphate synthesis in Escherichia coli K12.大肠杆菌K12中氨甲酰磷酸合成的生理学与遗传学
Mol Gen Genet. 1974;133(4):299-316. doi: 10.1007/BF00332706.
7
Biosynthesis and metabolism of arginine in bacteria.细菌中精氨酸的生物合成与代谢
Microbiol Rev. 1986 Sep;50(3):314-52. doi: 10.1128/mr.50.3.314-352.1986.
8
On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.γ-谷氨酰半胱氨酸合成酶活性位点硫醇：与催化、抑制和调节的关系
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2464-8. doi: 10.1073/pnas.85.8.2464.
9
Identification of a highly reactive threonine residue at the active site of gamma-glutamyl transpeptidase.γ-谷氨酰转肽酶活性位点高反应性苏氨酸残基的鉴定
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1706-9. doi: 10.1073/pnas.87.5.1706.
10
Inhibition of amino acid transport into lymphoid cells by the glutamine analog L-2-amino-4-oxo-5-chloropentanoate.谷氨酰胺类似物L-2-氨基-4-氧代-5-氯戊酸对氨基酸转运至淋巴细胞的抑制作用。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):4932-5. doi: 10.1073/pnas.76.10.4932.