大鼠孕期和哺乳期小肠的适应性变化
Adaptation of the small intestine during pregnancy and lactation in the rat.
作者信息
Burdett K, Reek C
出版信息
Biochem J. 1979 Nov 15;184(2):245-51. doi: 10.1042/bj1840245.
Abstract
During pregnancy and lactation in the rat the small intestine in general and the mucosal epithelium in particular gain weight. The specific activities of sucrase, lactate dehydrogenase and succinate-tetrazolium reductase remain constant and those of glucose 6-phosphate dehydrogenase and isocitrate dehydrogenase increase. There is no evidence that the reported decrease in absorption per unit area or weight of mucosal epithelium during pregnancy and lactation is due to decreases in enzyme activities within the epithelium. The pattern of enzyme change shows that the response of the gut to the stimuli of pregnancy and lactation must be a complex one, possibly involving increases in the specific activities of some enzymes.
摘要
在大鼠的怀孕和哺乳期间，小肠总体上，尤其是黏膜上皮会增重。蔗糖酶、乳酸脱氢酶和琥珀酸 - 四氮唑还原酶的比活性保持恒定，而葡萄糖6 - 磷酸脱氢酶和异柠檬酸脱氢酶的比活性增加。没有证据表明，在怀孕和哺乳期间，每单位面积或重量的黏膜上皮吸收减少是由于上皮内酶活性降低所致。酶变化模式表明，肠道对怀孕和哺乳刺激的反应必定是复杂的，可能涉及某些酶比活性的增加。
相似文献
1
Adaptation of the small intestine during pregnancy and lactation in the rat.大鼠孕期和哺乳期小肠的适应性变化
Biochem J. 1979 Nov 15;184(2):245-51. doi: 10.1042/bj1840245.
2
Activities of some metabolic enzymes in the small intestinal mucosa during pregnancy and lactation in the rat.
J Reprod Fertil. 1980 Sep;60(1):231-6. doi: 10.1530/jrf.0.0600231.
3
Enzyme changes in rat small intestine during pregnancy and lactation.
Histochem J. 1978 May;10(3):343-7. doi: 10.1007/BF01007564.
4
Role of the small intestine in postpartum weight retention in mice.小肠在小鼠产后体重维持中的作用。
Am J Clin Nutr. 2003 Dec;78(6):1178-87. doi: 10.1093/ajcn/78.6.1178.
5
Regulation of 6-phosphofructo-1-kinase from the epithelial cells of rat small intestine during pregnancy and lactation.
Biochim Biophys Acta. 1991 Aug 6;1074(3):357-62. doi: 10.1016/0304-4165(91)90085-u.
6
The effect of pregnancy and lactation on food intake, gastrointestinal anatomy and the absorptive capacity of the small intestine in the albino rat.
Br J Nutr. 1975 Jan;33(1):17-32. doi: 10.1079/bjn19750005.
7
The influence of pregnancy and lactation on the morphology and absorptive capacity of the rat small intestine.
Clin Sci. 1970 Mar;38(3):287-95. doi: 10.1042/cs0380287.
8
Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation.多胺与肠道生长：哺乳期适应性过程中鸟氨酸脱羧酶活性的绝对需求。
Am J Physiol. 1984 Nov;247(5 Pt 1):G553-7. doi: 10.1152/ajpgi.1984.247.5.G553.
9
Morphological adaptive changes of small intestinal tract regions due to pregnancy and lactation in rats.大鼠妊娠和哺乳期小肠各段的形态学适应性变化
Ann Nutr Metab. 1994;38(5):295-300. doi: 10.1159/000177824.
10
The mechanism for small-bowel adaptation in lactating rats.
Clin Sci Mol Med. 1976 Nov;51(5):427-33. doi: 10.1042/cs0510427.
引用本文的文献
1
Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy.小鼠孕期肠道葡萄糖吸收的解剖学、分子学和功能决定因素的差异变化。
Physiol Rep. 2025 Aug;13(15):e70493. doi: 10.14814/phy2.70493.
2
The intestine and the microbiota in maternal glucose homeostasis during pregnancy.肠道和微生物群在妊娠期间母体葡萄糖稳态中的作用。
J Endocrinol. 2022 Feb 25;253(1):R1-R19. doi: 10.1530/JOE-21-0354.
3
Effects of incubation and chick rearing on intestinal morphology, digestive enzyme activities, and mRNA expression of nutrient transporter genes in the pigeon (Columba livia) under artificial farming conditions.人工饲养条件下孵化和育雏对鸽子（Columba livia）肠道形态、消化酶活性和营养转运体基因 mRNA 表达的影响。
Poult Sci. 2020 May;99(5):2785-2797. doi: 10.1016/j.psj.2019.12.064. Epub 2020 Mar 11.
4
Determination of the changes on the small intestine of pregnant mice by histological, enzyme histochemical, and immunohistochemical methods.通过组织学、酶组织化学和免疫组织化学方法测定妊娠小鼠小肠的变化。
Turk J Gastroenterol. 2019 Oct;30(10):917-924. doi: 10.5152/tjg.2019.18681.
5
Role of the Small Intestine in Developmental Programming: Impact of Maternal Nutrition on the Dam and Offspring.小肠在发育编程中的作用：母体营养对母体和后代的影响。
Adv Nutr. 2016 Jan;7(1):169-78. doi: 10.3945/an.115.010405.
6
Expression of transcripts related to intestinal ion and nutrient absorption in pregnant and lactating rats as determined by custom-designed cDNA microarray.通过定制的cDNA微阵列测定怀孕和哺乳期大鼠中与肠道离子和营养吸收相关转录本的表达。
Mol Cell Biochem. 2014 Jun;391(1-2):103-16. doi: 10.1007/s11010-014-1992-8. Epub 2014 Feb 12.
7
The physiological costs of reproduction in small mammals.小型哺乳动物繁殖的生理成本。
Philos Trans R Soc Lond B Biol Sci. 2008 Jan 27;363(1490):375-98. doi: 10.1098/rstb.2007.2145.
8
Adaptation of the maternal intestine during lactation.哺乳期母体肠道的适应性变化。
J Mammary Gland Biol Neoplasia. 1997 Jul;2(3):243-52. doi: 10.1023/a:1026332304435.
9
Protein metabolism in the mouse during pregnancy and lactation.小鼠在怀孕和哺乳期间的蛋白质代谢。
Biochem J. 1987 Nov 15;248(1):251-7. doi: 10.1042/bj2480251.
10
本文引用的文献
1
METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES.肠道双糖酶的测定方法。
Anal Biochem. 1964 Jan;7:18-25. doi: 10.1016/0003-2697(64)90115-0.
2
Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat.哺乳期大鼠消化道的肥大和增生性变化。
J Pathol Bacteriol. 1963 Jan;85:179-88. doi: 10.1002/path.1700850117.
3
Lactic dehydrogenase activity in blood.血液中的乳酸脱氢酶活性。
Proc Soc Exp Biol Med. 1955 Oct;90(1):210-3. doi: 10.3181/00379727-90-21985.
4
Cell proliferation studies in the intestinal epithelium of the rat. Hyperplasia during lactation.大鼠肠上皮细胞增殖研究。哺乳期的增生现象。
Exp Cell Res. 1967 May;46(2):428-40. doi: 10.1016/0014-4827(67)90079-1.
5
Histochemical changes in the rat small intestine associated with enhanced absorption after high bulk feeding.
Enzymol Biol Clin (Basel). 1965;5(4):231-44. doi: 10.1159/000457999.
6
The metabolism of the small intestine. Oxygen uptake and L-lactate production along the length of the small intestine of the rat and guinea pig.小肠的新陈代谢。大鼠和豚鼠小肠各段的氧摄取及L-乳酸生成。
Comp Biochem Physiol. 1968 Mar;24(3):745-61. doi: 10.1016/0010-406x(68)90787-1.
7
The influence of pregnancy and lactation on the morphology and absorptive capacity of the rat small intestine.
Clin Sci. 1970 Mar;38(3):287-95. doi: 10.1042/cs0380287.
8
Development of mitochondrial enzyme activities in rat-small-intestinal epithelium.大鼠小肠上皮中线粒体酶活性的发育
Eur J Biochem. 1971 Dec 10;23(3):429-34. doi: 10.1111/j.1432-1033.1971.tb01637.x.
9
Studies on the fractionation of mucosal homogenates from the small intestine.小肠黏膜匀浆的分级分离研究。
Biochem J. 1965 Dec;97(3):629-42. doi: 10.1042/bj0970629.
10
The influence of changing cell kinetics on functional differentiation in the small intestine of the rat. A study of enzymes involved in carbohydrate metabolism.
J Histochem Cytochem. 1974 May;22(5):352-60. doi: 10.1177/22.5.352.
Zotero 插件