大鼠孕期和哺乳期小肠的适应性变化
Adaptation of the small intestine during pregnancy and lactation in the rat.
作者信息
Burdett K, Reek C
出版信息
Biochem J. 1979 Nov 15;184(2):245-51. doi: 10.1042/bj1840245.
Abstract
During pregnancy and lactation in the rat the small intestine in general and the mucosal epithelium in particular gain weight. The specific activities of sucrase, lactate dehydrogenase and succinate-tetrazolium reductase remain constant and those of glucose 6-phosphate dehydrogenase and isocitrate dehydrogenase increase. There is no evidence that the reported decrease in absorption per unit area or weight of mucosal epithelium during pregnancy and lactation is due to decreases in enzyme activities within the epithelium. The pattern of enzyme change shows that the response of the gut to the stimuli of pregnancy and lactation must be a complex one, possibly involving increases in the specific activities of some enzymes.
摘要
在大鼠的怀孕和哺乳期间，小肠总体上，尤其是黏膜上皮会增重。蔗糖酶、乳酸脱氢酶和琥珀酸 - 四氮唑还原酶的比活性保持恒定，而葡萄糖6 - 磷酸脱氢酶和异柠檬酸脱氢酶的比活性增加。没有证据表明，在怀孕和哺乳期间，每单位面积或重量的黏膜上皮吸收减少是由于上皮内酶活性降低所致。酶变化模式表明，肠道对怀孕和哺乳刺激的反应必定是复杂的，可能涉及某些酶比活性的增加。
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本文引用的文献
1
METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES.肠道双糖酶的测定方法。
Anal Biochem. 1964 Jan;7:18-25. doi: 10.1016/0003-2697(64)90115-0.
2
Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat.哺乳期大鼠消化道的肥大和增生性变化。
J Pathol Bacteriol. 1963 Jan;85:179-88. doi: 10.1002/path.1700850117.
3
Lactic dehydrogenase activity in blood.血液中的乳酸脱氢酶活性。
Proc Soc Exp Biol Med. 1955 Oct;90(1):210-3. doi: 10.3181/00379727-90-21985.
4
Cell proliferation studies in the intestinal epithelium of the rat. Hyperplasia during lactation.大鼠肠上皮细胞增殖研究。哺乳期的增生现象。
Exp Cell Res. 1967 May;46(2):428-40. doi: 10.1016/0014-4827(67)90079-1.
5
Histochemical changes in the rat small intestine associated with enhanced absorption after high bulk feeding.高容积喂养后大鼠小肠组织化学变化与吸收增强相关
Enzymol Biol Clin (Basel). 1965;5(4):231-44. doi: 10.1159/000457999.
6
The metabolism of the small intestine. Oxygen uptake and L-lactate production along the length of the small intestine of the rat and guinea pig.小肠的新陈代谢。大鼠和豚鼠小肠各段的氧摄取及L-乳酸生成。
Comp Biochem Physiol. 1968 Mar;24(3):745-61. doi: 10.1016/0010-406x(68)90787-1.
7
The influence of pregnancy and lactation on the morphology and absorptive capacity of the rat small intestine.
Clin Sci. 1970 Mar;38(3):287-95. doi: 10.1042/cs0380287.
8
Development of mitochondrial enzyme activities in rat-small-intestinal epithelium.大鼠小肠上皮中线粒体酶活性的发育
Eur J Biochem. 1971 Dec 10;23(3):429-34. doi: 10.1111/j.1432-1033.1971.tb01637.x.
9
Studies on the fractionation of mucosal homogenates from the small intestine.小肠黏膜匀浆的分级分离研究。
Biochem J. 1965 Dec;97(3):629-42. doi: 10.1042/bj0970629.
10
The influence of changing cell kinetics on functional differentiation in the small intestine of the rat. A study of enzymes involved in carbohydrate metabolism.
J Histochem Cytochem. 1974 May;22(5):352-60. doi: 10.1177/22.5.352.
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