Steel S J, Winstanley D P
Thorax. 1969 Sep;24(5):576-84. doi: 10.1136/thx.24.5.576.
During the last five years 140 biopsies of the lung or pleura have been performed with a high-speed air-drill. A specially designed trephine, 2·1 mm. in bore, proved effective in obtaining adequate specimens from patients with diffuse lung lesions. With this method 111 out of 119 (93%) consecutive lung biopsies were successful in producing specimens of lung tissue for histological examination and 101 (85%) of these biopsies were diagnostically significant. Conditions such as sarcoidosis, berylliosis, alveolar proteinosis, polyarteritis nodosa, asbestosis, and diffuse interstitial pulmonary fibrosis were conclusively diagnosed. Complications were not serious and the commonest, pneumothorax, which occurred in 26% of the lung biopsies, was usually asymptomatic. The procedure is rapid and painless and breath-holding is unnecessary. It is performed under local anaesthesia and can be repeated, if required, thus having many advantages over biopsy by open thoracotomy. However, full thoracic surgical cover should be available. Indications include diffuse and localized lesions of the lung or pleura where a definitive diagnosis is required for the purpose of treatment, prognosis, or a claim for industrial compensation.
在过去五年中，使用高速气钻对140例肺或胸膜进行了活检。一种特别设计的内径为2.1毫米的环钻，被证明在从患有弥漫性肺部病变的患者中获取足够的标本方面是有效的。用这种方法，119例连续肺活检中有111例（93%）成功获取了肺组织标本用于组织学检查，其中101例（85%）活检具有诊断意义。结节病、铍中毒、肺泡蛋白沉积症、结节性多动脉炎、石棉沉着病和弥漫性间质性肺纤维化等疾病得到了明确诊断。并发症并不严重，最常见的气胸发生在26%的肺活检中，通常无症状。该操作快速且无痛，无需屏气。它在局部麻醉下进行，如果需要可以重复，因此比开胸活检有许多优点。然而，应具备全面的胸外科支持。适应症包括肺或胸膜的弥漫性和局限性病变，为了治疗、预后或工业赔偿索赔而需要明确诊断的情况。
