大鼠失神经支配股薄肌前肌的一些特性。
Some properties of the denervated anterior gracilis muscle of the rat.
作者信息
Turkanis S A
出版信息
Br J Pharmacol. 1969 Oct;37(2):414-24. doi: 10.1111/j.1476-5381.1969.tb10578.x.
Abstract
- Microdrops of acetylcholine (ACh) were topically applied to denervated, mammalian skeletal muscle in vivo, and ACh-evoked depolarization and contracture were recorded simultaneously.2. Contracture tension was directly proportional to the degree of ACh-elicited depolarization.3. Atropine and (+)-tubocurarine increased the amount of ACh required to produce a given amount of depolarization, but these anticholinergic agents did not alter the relationship between the degree of ACh-evoked depolarization and contracture tension.4. Topically applied catecholamines did not produce either depolarization or contracture, despite the fact that parenterally administered catecholamines elicited both responses.
摘要
将乙酰胆碱（ACh）微滴局部应用于体内去神经支配的哺乳动物骨骼肌，并同时记录ACh诱发的去极化和挛缩。
挛缩张力与ACh诱发的去极化程度直接成正比。
阿托品和（+）-筒箭毒碱增加了产生给定程度去极化所需的ACh量，但这些抗胆碱能药物并未改变ACh诱发的去极化程度与挛缩张力之间的关系。
尽管胃肠外给予儿茶酚胺会引发这两种反应，但局部应用儿茶酚胺既不会产生去极化也不会产生挛缩。
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