外部钙和镁离子对失神经肌肉对乙酰胆碱反应的影响。
The effect of external calcium and magnesium ions on the response of denervated muscle to acetylcholine.
作者信息
Gordon T
出版信息
J Physiol. 1976 Mar;255(3):575-86. doi: 10.1113/jphysiol.1976.sp011296.
Abstract
- The effect of external Ca and Mg on the membrane depolarization and contracture of rat denervated muscle in response to acetylcholine, ACh, was studied. 2. Raising external Ca concentration reduced the rate of rise and the amplitude of the ACh contracture, and prolonged its time course. 3. Increasing external Ca reduced the membrane depolarization in response to ACh. The dose increment required to elicit depolarization in high Ca concentration increased with external Ca, and was greater for depolarization than for contracture. 4. External Mg was less effect than Ca in reducing ACh depolarization but was more effective in reducing contracture. In contrast to Ca, Mg did not alter the time course of relaxation. 5. It is concluded that external Ca has two opposing effects on the ACh contracture: one of stabilizing the membrane and the other of increasing intracellular Ca concentration. External Mg may interfere with Ca influx and hence reduce contractility.
摘要
- 研究了细胞外钙和镁对大鼠失神经肌肉对乙酰胆碱（ACh）反应时膜去极化和挛缩的影响。2. 提高细胞外钙浓度可降低ACh挛缩的上升速率和幅度，并延长其时程。3. 增加细胞外钙可降低对ACh的膜去极化。在高钙浓度下引发去极化所需的剂量增量随细胞外钙增加，且去极化所需剂量增量大于挛缩所需剂量增量。4. 细胞外镁在降低ACh去极化方面比钙的作用小，但在降低挛缩方面更有效。与钙不同，镁不改变舒张时程。5. 得出结论：细胞外钙对ACh挛缩有两种相反作用：一种是稳定膜，另一种是增加细胞内钙浓度。细胞外镁可能干扰钙内流，从而降低收缩性。
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