注射利血平或肾上腺素后大鼠胃黏膜和肺中组胺的形成。
Histamine formation in rat gastric mucosa and lung after injecting reserpine or adrenaline.
作者信息
Rosengren E, Svensson S E
出版信息
Br J Pharmacol. 1969 Nov;37(3):659-65. doi: 10.1111/j.1476-5381.1969.tb08504.x.
Abstract
- In rats the effect of reserpine, adrenaline and gastrin on the histamine forming capacity (HFC) of gastric mucosa and lung was examined.2. Intraperitoneal reserpine as well as subcutaneous adrenaline produced a great increase in HFC of gastric mucosa but a great decrease in HFC of lung. After reserpine the HFC of lung was almost abolished.3. As the HFC changes produced by reserpine occurred also after demedullation of the suprarenals--the changes in the mucosa were in fact accentuated--release of the medullary hormones by the reserpine does not account for these changes.4. Subcutaneous gastrin caused a great increase in HFC of the gastric mucosa but did not affect the HFC in lung.5. The possible role of release of gastrin and corticosteroids for the reserpine-induced HFC changes is discussed because it is known that reserpine releases gastrin and corticosteroids and that cortisone produces HFC changes in gastric mucosa and lung.
摘要
研究了利血平、肾上腺素和胃泌素对大鼠胃黏膜和肺组织组胺生成能力（HFC）的影响。
腹腔注射利血平和皮下注射肾上腺素均使胃黏膜的HFC大幅增加，但使肺组织的HFC大幅降低。利血平处理后，肺组织的HFC几乎完全消失。
由于肾上腺髓质切除后利血平仍能产生HFC变化——事实上黏膜的变化更为明显——因此利血平释放髓质激素并不能解释这些变化。
皮下注射胃泌素可使胃黏膜的HFC大幅增加，但对肺组织的HFC无影响。
讨论了胃泌素和皮质类固醇释放对于利血平诱导的HFC变化可能发挥的作用，因为已知利血平可释放胃泌素和皮质类固醇，且可的松可引起胃黏膜和肺组织的HFC变化。
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