半胱胺给药后胃黏膜组胺、组胺生成能力（HFC）及血浆胃泌素水平
Gastric mucosal histamine, histamine formation capacity (HFC) and plasma gastrin after cysteamine administration.
作者信息
Man W K, Boesby S, Spencer J
出版信息
Br J Exp Pathol. 1984 Dec;65(6):759-65.
Abstract
Cysteamine administration is followed by stomach and duodenal ulcers in rats. We aimed to establish a time relationship between changes in gastric mucosal histamine, histamine formation capacity (HFC) and plasma gastrin after cysteamine administration. Up to 4 h after cysteamine s.c., no ulcers were found. Plasma gastrin rose after cysteamine and was higher than in controls 2h after injection. Mucosal histamine fell after 4h; no other significant changes were found in mucosal histamine and HFC. A direct correlation was found between plasma gastrin and HFC in both controls and after cysteamine. It is suggested that the changes indicate that cysteamine releases gastrin, which increases HFC and thus histamine. The fall in histamine seems to indicate utilization of histamine in acid production.
摘要
给大鼠注射半胱胺后会出现胃和十二指肠溃疡。我们旨在确定注射半胱胺后胃黏膜组胺、组胺生成能力（HFC）和血浆胃泌素变化之间的时间关系。皮下注射半胱胺后长达4小时，未发现溃疡。注射半胱胺后血浆胃泌素升高，注射后2小时高于对照组。4小时后黏膜组胺下降；黏膜组胺和HFC未发现其他显著变化。在对照组和注射半胱胺后，血浆胃泌素与HFC之间均发现直接相关性。提示这些变化表明半胱胺释放胃泌素，胃泌素增加HFC从而增加组胺。组胺的下降似乎表明组胺用于产酸。
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