前列腺素E1从大鼠膈神经-膈肌标本中的释放。
The release of prostaglandin E1 from the rat phrenic nerve-diaphragm preparation.
作者信息
Laity J L
出版信息
Br J Pharmacol. 1969 Nov;37(3):698-704. doi: 10.1111/j.1476-5381.1969.tb08508.x.
Abstract
- The release of prostaglandin E(1) from the rat phrenic nerve-diaphragm preparation during tetanic contraction of the muscle in response to nerve stimulation is reported. Tentative identification of the prostaglandin depended on solvent extraction column and thin-layer chromatography and parallel biological assay.2. Polar lipid substances were released from the preparation in the absence of nerve stimulation by (+)-tubocurarine and noradrenaline.3. The output on nerve stimulation was not abolished by (+)-tubocurarine, hemicholinium, bretylium or phenoxybenzamine added to the bath.4. The possible origin of these prostaglandins is discussed.
摘要
据报道，在大鼠膈神经 - 膈肌标本中，当肌肉因神经刺激发生强直收缩时，会释放前列腺素E(1)。对前列腺素的初步鉴定依赖于溶剂萃取柱、薄层色谱法和平行生物测定。
在没有神经刺激的情况下，(+)-筒箭毒碱和去甲肾上腺素会使标本释放极性脂质物质。
加入浴槽中的(+)-筒箭毒碱、半胱氨酸、溴苄铵或酚苄明不会消除神经刺激时的释放量。
讨论了这些前列腺素可能的来源。
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