Wolters M J, Leeuwin R S
Neurology. 1976 Jun;26(6 PT 1):574-8. doi: 10.1212/wnl.26.6.574.
A marked protective action of the corticosteroids prednisolone, hydrocortisone, and dexamethasone has been shown on a hypothetical model of myasthenia gravis, using the rat phrenic nerve-diaphragm preparation treated with hemicholinium-3. Dexamethasone is much more effective than prednisolone, and hydrocortisone is the least effective. Prednisolone has no effect on a neuromuscular block caused by choline, decamethonium, physostigmine, d-tubocurarine, and a high or low calcium ion concentration. The possible implications of the present study for myasthenic disease are discussed. It is tentatively concluded that the site of action of corticosteroids in myasthenia gravis is located presynaptically.
在使用经3-羟甲基胆碱处理的大鼠膈神经-膈肌标本建立的重症肌无力假说模型上，已证实皮质类固醇泼尼松龙、氢化可的松和地塞米松具有显著的保护作用。地塞米松比泼尼松龙有效得多，而氢化可的松效果最差。泼尼松龙对由胆碱、十烃季铵、毒扁豆碱、d-筒箭毒碱以及高钙或低钙离子浓度引起的神经肌肉阻滞没有作用。讨论了本研究对重症肌无力疾病可能的影响。初步得出结论，皮质类固醇在重症肌无力中的作用部位位于突触前。
