Kleinschmidt A K, Moss J, Lane D M
Science. 1969 Dec 5;166(3910):1276-8. doi: 10.1126/science.166.3910.1276.
Acetyl coenzyme A carboxylases purified from several animal tissues exist as enzymatically active polymeric filaments of high molecular weight and have simillar electron microscopic, hydrodynamic, and catalytic properties. These filaments reversibly dissociate into inactive protomers of uniform size. Their re-assembly into catalytically active filaments is promoted by the presence of an allosteric activator.
从几种动物组织中纯化得到的乙酰辅酶A羧化酶以具有酶活性的高分子量聚合丝形式存在，并且具有相似的电子显微镜、流体动力学和催化特性。这些丝可逆地解离成大小均匀的无活性单体。变构激活剂的存在促进它们重新组装成具有催化活性的丝。
