Chemnitz G, Nevermann L, Schmidt E, Schmidt F W, Lobers J
Clin Biochem. 1979 Dec;12(6):277-81. doi: 10.1016/s0009-9120(79)80128-9.
Total CK and CK isoenzyme activity in serum was investigated during pregnancy, labor and after delivery as well as in cord blood. Total CK was decreased in the second trimester of pregnancy but increased in late pregnancy. Low CK-MB activity in serum was found in patients with early labor pains. CK-BB activity could never be detected during pregnancy. Total CK and isoenzyme activity increased after delivery. The rise of total CK and CK-MB in maternal serum is directly correlated with the following: type of delivery, duration of labor, parity of the mother, and birth weight. From this it can be deduced that postpartum CK levels depend on skeletal muscle activity as well as on the activity of uterine muscle. Prematures and infants "small for date" have significantly lower total CK and slightly more elevated CK-BB activity in cord blood than children of normal maturity. CK-BB activity is much more pronounced in high risk patients with low Apgar score.
对孕期、分娩时、产后以及脐带血中的血清总肌酸激酶（CK）和CK同工酶活性进行了研究。孕期中期血清总CK降低，但孕晚期升高。早产阵痛患者血清中CK-MB活性较低。孕期从未检测到CK-BB活性。产后总CK和同工酶活性增加。母体血清中总CK和CK-MB的升高与以下因素直接相关：分娩类型、产程、母亲的胎次和出生体重。由此可以推断，产后CK水平取决于骨骼肌活动以及子宫肌活动。与正常成熟度的儿童相比，早产儿和“小于胎龄儿”脐带血中的总CK明显较低，CK-BB活性略有升高。低阿氏评分的高危患者中CK-BB活性更为明显。
