Jenkins C B, Ghidini A, Spong C Y, Eglinton G S, Pezzullo J C, Michejda M
Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington, DC 20007, USA.
Fetal Diagn Ther. 1997 Nov-Dec;12(6):356-9. doi: 10.1159/000264505.
We hypothesized that maternal serum levels of the isoenzyme creatine kinase (CK)-BB, which is highly expressed in the placenta, may be elevated during the early second trimester in gestations destined to deliver prematurely or of a small-for-gestational-age infant (birthweight below 10th percentile). To test this hypothesis, we compared maternal serum CK-BB levels and percentage of CK-BB over total CK, in 69 normal pregnancies (delivering at term of appropriate-for-gestational-age infants) with those of 25 cases complicated by preterm delivery at < or = 34 weeks (n = 14), of a small-for-gestational-age infant (n = 8), or both (n = 3). No differences were present in maternal serum CK BB levels between normal and complicated pregnancies. Moreover, no correlation was found between gestational age at delivery and CK BB levels (r = 0.03; p = 0.7).
我们假设，在胎盘组织中高表达的肌酸激酶（CK）同工酶BB的母体血清水平，在那些注定会早产或分娩出小于胎龄儿（出生体重低于第10百分位数）的妊娠中期早期可能会升高。为了验证这一假设，我们比较了69例正常妊娠（足月分娩出适于胎龄儿）的母体血清CK-BB水平以及CK-BB占总CK的百分比，与25例并发小于34周早产（n = 14）、小于胎龄儿（n = 8）或两者皆有（n = 3）的病例的上述指标。正常妊娠和并发妊娠的母体血清CK-BB水平没有差异。此外，未发现分娩时的孕周与CK-BB水平之间存在相关性（r = 0.03；p = 0.7）。
