Andronikou S, Bairaktari E, Vasiliadou A D, Stefos T, Lolis D, Tsolas O, Lapatsanis P D
Child Health Department, University of Ioannina Medical School, Greece.
Fetal Diagn Ther. 1995 Jan-Feb;10(1):1-6. doi: 10.1159/000264182.
Creatine kinase-brain isoenzyme activity (CK-BB) was measured longitudinally in the serum of 31 pregnant women in the first stage of labor (early and advanced), at delivery, and 1, 6 and 24 h after delivery, in the umbilical cord and in the serum of their neonates on the first day of life. There was no increase in serum CK-BB values of mothers that delivered normally (n = 15) or had an elective cesarean section (n = 5). Pregnant women with signs of fetal distress had an increase in CK-BB levels in the first stage of labor (mean +/- SD 4.5 +/- 4.9 U/l, p < 0.03) and 6 h after delivery (12 +/- 4 U/l, p < 0.0001). Neonates with intrauterine stress also had an increase in their CK-BB to 144 +/- 116 U/l at 6 h of life, in comparison with babies born without signs of stress. It appears that CK-BB during labor and in the first hours of life may be indicative of intrauterine stress.
在31名处于第一产程（早期和晚期）、分娩时、分娩后1小时、6小时和24小时的孕妇血清中，以及在其新生儿出生第一天的脐带血和血清中，纵向测量了肌酸激酶脑型同工酶活性（CK-BB）。正常分娩的母亲（n = 15）或接受择期剖宫产的母亲（n = 5）的血清CK-BB值没有升高。有胎儿窘迫迹象的孕妇在第一产程中CK-BB水平升高（平均±标准差 4.5±4.9 U/l，p < 0.03），分娩后6小时升高（12±4 U/l，p < 0.0001）。与无宫内应激迹象出生的婴儿相比，有宫内应激的新生儿在出生6小时时其CK-BB也升高至144±116 U/l。看来分娩期间和出生后最初几小时的CK-BB可能提示宫内应激。
