Oka M, Miki T, Hama H, Yamamuro T
Clin Orthop Relat Res. 1979 Nov-Dec(145):264-72.
As sex hormones are considered to play a role in the etiology of the slipped upper femoral epiphysis, the influence of sex hormones on the mechanical strength of the epiphyseal plate was investigated in 310 female and 70 male rats. Ovariectomy weakened the strength of the growth plate while orchiectomy strengthened it. Estrogen given after ovariectomy, markedly strengthened the plate. Histologic examination revealed that the width of the growth plate was narrower in the mechanically stronger group. Hydroxyproline content increased and hexosamine content decreased in the epiphyseal plates of the mechanically stronger group. These observations confirm the view that sex hormones, especially estrogen, regulate the mechanical, morphologic, and biochemical functions of the growth plate.
由于性激素被认为在股骨头骨骺滑脱的病因学中起作用，因此在310只雌性和70只雄性大鼠中研究了性激素对骺板机械强度的影响。卵巢切除术削弱了生长板的强度，而睾丸切除术则增强了它的强度。卵巢切除术后给予雌激素，显著增强了生长板的强度。组织学检查显示，在机械强度较强的组中，生长板的宽度较窄。机械强度较强组的骺板中羟脯氨酸含量增加，己糖胺含量减少。这些观察结果证实了性激素，尤其是雌激素，调节生长板的机械、形态和生化功能这一观点。
