Stocks A E, Martin F I
Br Med J. 1969 Nov 15;4(5680):397-9. doi: 10.1136/bmj.4.5680.397.
In 27 maturity-onset diabetics of more than 10 years' duration there was a significant tendency for both atherosclerosis and microangiopathy to be associated with a reduction in the acute hypoglycaemic effect of intravenous beef insulin. This finding is identical to that in a group of 51 insulin-dependent diabetics previously reported.It is suggested that insulin insensitivity probably precedes the appearance of vascular disease in diabetes and may be implicated in its production.
在病程超过10年的27例成年起病的糖尿病患者中，动脉粥样硬化和微血管病变均有显著倾向与静脉注射牛胰岛素的急性降血糖作用降低相关。这一发现与先前报道的一组51例胰岛素依赖型糖尿病患者的情况相同。有人提出，胰岛素不敏感可能在糖尿病血管疾病出现之前就已存在，并且可能与其发生有关。
