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1
Immunity to staphylococcal infection in mice: effect of living versus killed vaccine, role of circulating antibody, and induction of protection-inducing antigen(s) in vitro.小鼠对葡萄球菌感染的免疫:活疫苗与灭活疫苗的效果、循环抗体的作用以及体外诱导保护性抗原的产生
J Bacteriol. 1969 Nov;100(2):745-50. doi: 10.1128/jb.100.2.745-750.1969.
2
Antibody response to Staphylococcus aureus in rabbits: sequence of immunoglobulin synthesis and its correlation with passive protection in mice.兔对金黄色葡萄球菌的抗体反应:免疫球蛋白合成顺序及其与小鼠被动保护的相关性
J Bacteriol. 1968 Nov;96(5):1540-5. doi: 10.1128/jb.96.5.1540-1545.1968.
3
Induction of resistance with heat-killed compact-type strains of Staphylococcus aureus against challenge with the diffuse variant of the Smith strain of Staphylococcus aureus.用热灭活的致密型金黄色葡萄球菌菌株诱导对金黄色葡萄球菌史密斯菌株的弥漫变异株攻击的抗性。
Infect Immun. 1975 Nov;12(5):939-42. doi: 10.1128/iai.12.5.939-942.1975.
4
Cross protection in mice with the Smith diffuse stain of Staphylococcus aureus versus a type Ia strain of group B streptococci.金黄色葡萄球菌史密斯弥漫染色株对B族链球菌Ia型菌株在小鼠中的交叉保护作用。
Can J Microbiol. 1982 Jul;28(7):726-32. doi: 10.1139/m82-111.
5
Passive protection by human serum in mice infected with encapsulated Staphylococcus aureus.人血清对感染包膜金黄色葡萄球菌小鼠的被动保护作用。
J Med Microbiol. 1979 Aug;12(3):277-82. doi: 10.1099/00222615-12-3-277.
6
The characterization of antibacterial antibodies in bovine immune sera to Staphylococcus aureus.牛抗金黄色葡萄球菌免疫血清中抗菌抗体的特性分析
Microbiol Immunol. 1978;22(1):1-13. doi: 10.1111/j.1348-0421.1978.tb00343.x.
7
Mouse virulent strain of Staphylococcus epidermidis. Relation of antiphagocytic activity to the protection-inducing antigen.表皮葡萄球菌小鼠强毒株。抗吞噬活性与诱导保护抗原的关系。
Jpn J Microbiol. 1976 Jun;20(3):209-17.
8
Isolation and properties of a surface antigen of Staphylococcus aureus.金黄色葡萄球菌一种表面抗原的分离与特性
J Exp Med. 1962 Feb 1;115(2):295-311. doi: 10.1084/jem.115.2.295.
9
Immunological response to a strain of Staphylococcus epidermidis in the rabbit: production of protective antibody.兔子对表皮葡萄球菌菌株的免疫反应:保护性抗体的产生。
J Med Microbiol. 1978 Nov;11(4):371-7. doi: 10.1099/00222615-11-4-371.
10
Induction of resistance with heat-killed unencapsulated strains of Staphylococcus epidermidis against challenge with encapsulated strains of Staphylococcus epidermidis.用热灭活的表皮葡萄球菌非包膜菌株诱导对表皮葡萄球菌包膜菌株攻击的抗性。
Microbiol Immunol. 1989;33(4):277-86. doi: 10.1111/j.1348-0421.1989.tb01977.x.

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1
Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection.生物膜基质外蛋白诱导针对金黄色葡萄球菌生物膜感染的保护性免疫应答。
Infect Immun. 2014 Mar;82(3):1017-29. doi: 10.1128/IAI.01419-13. Epub 2013 Dec 16.
2
Safety and immunogenicity of a novel Staphylococcus aureus vaccine: results from the first study of the vaccine dose range in humans.一种新型金黄色葡萄球菌疫苗的安全性和免疫原性:人类疫苗剂量范围首次研究的结果。
Clin Vaccine Immunol. 2010 Dec;17(12):1868-74. doi: 10.1128/CVI.00356-10. Epub 2010 Oct 13.
3
Biological and Immunological Properties of Encapsulated Strains of Staphylococcus aureus from Human Sources.人源金黄色葡萄球菌包囊株的生物学和免疫学特性。
Infect Immun. 1970 Nov;2(5):528-32. doi: 10.1128/iai.2.5.528-532.1970.
4
Virulence of two mastitis strains of Staphylococcus aureus in bovine skin: enhancement by growth in high carbohydrate-high salt medium or in raw milk.两种金黄色葡萄球菌乳腺炎菌株在牛皮肤中的毒力:在高碳水化合物-高盐培养基或生牛奶中生长后毒力增强。
Infect Immun. 1973 Jun;7(6):865-72. doi: 10.1128/iai.7.6.865-872.1973.
5
Biological properties of the encapsulated Staphylococcus aureus M.包囊化金黄色葡萄球菌M的生物学特性
Infect Immun. 1974 Aug;10(2):389-97. doi: 10.1128/iai.10.2.389-397.1974.
6
Detection of capsular antigen production in unencapsulated strains of Staphylococcus aureus.未包膜金黄色葡萄球菌菌株中荚膜抗原产生的检测
Infect Immun. 1974 Apr;9(4):620-3. doi: 10.1128/iai.9.4.620-623.1974.
7
Human specific immunoglobulin protects against infection with common Staphylococcus in mice.人特异性免疫球蛋白可保护小鼠免受常见葡萄球菌感染。
Experientia. 1987 Mar 15;43(3):329-30. doi: 10.1007/BF01945572.
8
Chemical and biological properties of extracellular slime produced by Staphylococcus aureus grown in high-carbohydrate, high-salt medium.在高碳水化合物、高盐培养基中生长的金黄色葡萄球菌产生的细胞外黏液的化学和生物学特性。
Infect Immun. 1976 Mar;13(3):653-60. doi: 10.1128/iai.13.3.653-660.1976.
9
Comparison of subcutaneous and intraperitoneal staphylococcal infections in normal and complement-deficient mice.正常小鼠和补体缺陷小鼠皮下与腹腔葡萄球菌感染的比较
Infect Immun. 1976 Feb;13(2):399-406. doi: 10.1128/iai.13.2.399-406.1976.
10
Induction of resistance with heat-killed compact-type strains of Staphylococcus aureus against challenge with the diffuse variant of the Smith strain of Staphylococcus aureus.用热灭活的致密型金黄色葡萄球菌菌株诱导对金黄色葡萄球菌史密斯菌株的弥漫变异株攻击的抗性。
Infect Immun. 1975 Nov;12(5):939-42. doi: 10.1128/iai.12.5.939-942.1975.

本文引用的文献

1
Isolation and properties of a surface antigen of Staphylococcus aureus.金黄色葡萄球菌一种表面抗原的分离与特性
J Exp Med. 1962 Feb 1;115(2):295-311. doi: 10.1084/jem.115.2.295.
2
THE HETEROGENEITY OF THE IMMUNE RESPONSE.免疫反应的异质性
Science. 1964 Jul 31;145(3631):457-64. doi: 10.1126/science.145.3631.457.
3
Factors relating to the virulence of Staphylococci. II. Observations on four mouse-pathogenic strains.与葡萄球菌毒力相关的因素。II. 对四株小鼠致病菌株的观察
J Exp Med. 1962 Nov 1;116(5):589-99. doi: 10.1084/jem.116.5.589.
4
Acute infection of mice with Smith strain of Staphylococcus aureus.用金黄色葡萄球菌史密斯菌株对小鼠进行急性感染。
Science. 1958 Dec 19;128(3338):1574-5. doi: 10.1126/science.128.3338.1574.
5
The virulence of Staphylococcus pyogenes for man; a study of the problems of wound infection.酿脓链球菌对人类的毒力;伤口感染问题研究
Br J Exp Pathol. 1957 Dec;38(6):573-86.
6
Relation of mucoid growth of Staphylococcus aureus to clumping factor reaction, morphology in serum-soft agar, and virulence.金黄色葡萄球菌黏液样生长与聚集因子反应、血清软琼脂中的形态及毒力的关系
J Bacteriol. 1968 Oct;96(4):902-8. doi: 10.1128/jb.96.4.902-908.1968.
7
Cellular reactions in the pathogenesis of staphylococcal infections.
Ann N Y Acad Sci. 1965 Jul 23;128(1):214-30. doi: 10.1111/j.1749-6632.1965.tb11640.x.
8
Antibody response to Staphylococcus aureus in rabbits: sequence of immunoglobulin synthesis and its correlation with passive protection in mice.兔对金黄色葡萄球菌的抗体反应:免疫球蛋白合成顺序及其与小鼠被动保护的相关性
J Bacteriol. 1968 Nov;96(5):1540-5. doi: 10.1128/jb.96.5.1540-1545.1968.
9
Mechanisms of resistance to staphylococcal infection: natural and acquired.对葡萄球菌感染的抵抗机制:天然的和后天获得的。
Ann N Y Acad Sci. 1965 Jul 23;128(1):301-34. doi: 10.1111/j.1749-6632.1965.tb11646.x.

小鼠对葡萄球菌感染的免疫:活疫苗与灭活疫苗的效果、循环抗体的作用以及体外诱导保护性抗原的产生

Immunity to staphylococcal infection in mice: effect of living versus killed vaccine, role of circulating antibody, and induction of protection-inducing antigen(s) in vitro.

作者信息

Ekstedt R D, Yoshida K

出版信息

J Bacteriol. 1969 Nov;100(2):745-50. doi: 10.1128/jb.100.2.745-750.1969.

DOI:10.1128/jb.100.2.745-750.1969
PMID:5354944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250153/
Abstract

Mice immunized by sublethal doses of living Staphylococcus aureus strains other than the Smith diffuse strain were significantly more resistant to challenge with the Smith diffuse strain than animals immunized with heat-killed organisms. The increased resistance observed was shown, by appropriate passive protection experiments with immune mouse sera, to be due to circulating antibody, probably of the IgM class. In addition, it was observed that strains of S. aureus other than the Smith diffuse strain, when cultured in a modified Staphylococcus 110 broth but not in Brain Heart Infusion, were capable of absorbing protective antibody from hyperimmune rabbit antiserum.

摘要

用除史密斯弥漫菌株之外的亚致死剂量活金黄色葡萄球菌菌株免疫的小鼠,比用热灭活菌免疫的动物对史密斯弥漫菌株攻击的抵抗力明显更强。通过用免疫小鼠血清进行适当的被动保护实验表明,观察到的抵抗力增强是由于循环抗体,可能是IgM类抗体。此外,还观察到,除史密斯弥漫菌株之外的金黄色葡萄球菌菌株,在改良的葡萄球菌110肉汤中培养时能够从超免疫兔抗血清中吸收保护性抗体,但在脑心浸液中培养时则不能。