小鼠对葡萄球菌感染的免疫：活疫苗与灭活疫苗的效果、循环抗体的作用以及体外诱导保护性抗原的产生
Immunity to staphylococcal infection in mice: effect of living versus killed vaccine, role of circulating antibody, and induction of protection-inducing antigen(s) in vitro.
作者信息
Ekstedt R D, Yoshida K
出版信息
J Bacteriol. 1969 Nov;100(2):745-50. doi: 10.1128/jb.100.2.745-750.1969.
Abstract
Mice immunized by sublethal doses of living Staphylococcus aureus strains other than the Smith diffuse strain were significantly more resistant to challenge with the Smith diffuse strain than animals immunized with heat-killed organisms. The increased resistance observed was shown, by appropriate passive protection experiments with immune mouse sera, to be due to circulating antibody, probably of the IgM class. In addition, it was observed that strains of S. aureus other than the Smith diffuse strain, when cultured in a modified Staphylococcus 110 broth but not in Brain Heart Infusion, were capable of absorbing protective antibody from hyperimmune rabbit antiserum.
摘要
用除史密斯弥漫菌株之外的亚致死剂量活金黄色葡萄球菌菌株免疫的小鼠，比用热灭活菌免疫的动物对史密斯弥漫菌株攻击的抵抗力明显更强。通过用免疫小鼠血清进行适当的被动保护实验表明，观察到的抵抗力增强是由于循环抗体，可能是IgM类抗体。此外，还观察到，除史密斯弥漫菌株之外的金黄色葡萄球菌菌株，在改良的葡萄球菌110肉汤中培养时能够从超免疫兔抗血清中吸收保护性抗体，但在脑心浸液中培养时则不能。
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