Boris M, Teubner D, Shinefield H
J Bacteriol. 1969 Nov;100(2):791-5. doi: 10.1128/jb.100.2.791-795.1969.
During the course of studying the effect of normal nasal flora on the growth of L-forms, a clear zone of inhibition was observed around colonies of many coagulase-negative staphylococci. Subsequent investigation demonstrated that Staphylococcus aureus and some S. albus strains produce a substance which is capable of markedly inhibiting the growth of stable staphylococcal and streptococcal L-forms. This interfering substance is separable from the staphylococcal organism and is diffusible through 1.5% agar, but not through a dialysis membrane. It is heat-stable.
在研究正常鼻腔菌群对L型菌生长的影响过程中，在许多凝固酶阴性葡萄球菌菌落周围观察到了明显的抑菌圈。后续研究表明，金黄色葡萄球菌和一些白色葡萄球菌菌株会产生一种物质，该物质能够显著抑制稳定的葡萄球菌和链球菌L型菌的生长。这种干扰物质可从葡萄球菌菌体中分离出来，能透过1.5%的琼脂，但不能透过透析膜。它具有热稳定性。
