Hagenah R
Fortschr Med. 1979 Nov 1;97(41):1840-4.
Recurrent axon collaterals of alpha-motoneurons formed with Renshaw cells cholinergic synapses. The effects of ethanol, pyritinol-HCl and type A botulinum toxin on this central nervous cholinergic synapse were studied. Ethanol caused a marked increase in Renshaw cell activity. The excitatory influence effects above all the Renshaw cell synapses directly. Pyritinol-HCl decreased the activity of Renshaw cells. The increase of Renshaw cell activity, caused by ethanol, changed into a decrease after pyritinol-HCl application so that pyritinol-HCl has a protective effect on this cholinergic system. The injection of the neurotoxin botulinum type A into the muscle or even into the ventral root was without effect on the Renshaw cell activity during the test period. Only the direct application of botulinum toxin type A into the spinal cord led to a decrease of the early and the late response of Renshaw cells. The results are discussed and the clinical relevance is considered. The cholinergic Renshaw cell synapse is not only considered as a special synapse but also as a model for cholinergic transmission which is assumed in several parts of the central nervous system.
α运动神经元的反复轴突侧支与闰绍细胞形成胆碱能突触。研究了乙醇、盐酸吡硫醇和A型肉毒杆菌毒素对这种中枢神经胆碱能突触的影响。乙醇使闰绍细胞活性显著增加。这种兴奋性影响首先直接作用于所有闰绍细胞突触。盐酸吡硫醇降低了闰绍细胞的活性。乙醇引起的闰绍细胞活性增加，在应用盐酸吡硫醇后转变为活性降低，因此盐酸吡硫醇对这个胆碱能系统具有保护作用。在试验期间，将A型肉毒杆菌神经毒素注射到肌肉甚至腹根中对闰绍细胞活性没有影响。只有将A型肉毒杆菌毒素直接应用于脊髓才会导致闰绍细胞早期和晚期反应降低。对结果进行了讨论并考虑了其临床相关性。胆碱能闰绍细胞突触不仅被视为一种特殊的突触，而且被视为中枢神经系统几个部位所假定的胆碱能传递模型。
