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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hagenah R, Benecke R, Wiegand H

Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;299(3):267-72. doi: 10.1007/BF00500319.

The central action of botulinum toxin A (BTA) on the cholinergic transmission at Renshaw cells (RCs) and on the RC-induced inhibition of Ia inhibitory interneurones (IaINs) was studied in anaesthetized cats. BTA was administered by application directly into the spinal cord, injection into a ventral root (L7) and/or injection into the triceps surae (GS) muscle. 2. A direct application of BTA into the spinal cord led to a decrease of the early and the late response of RCs. 3. When the neurotoxin was injected into the GS muscle, the RC activity remained unaffected during the test period (33-46 h after application). 4. No effect appeared up to 10 h after an injection into the ventral root L7. 5. The RC-induced inhibition on IaINs, when tested in animals with local botulismus, remained intact during the test period. 6. From the present results it is suggested that on the spinal level the central action of botulinum toxin predominantly passes on the motoneurones.

在麻醉猫身上研究了A型肉毒杆菌毒素（BTA）对闰绍细胞（RCs）胆碱能传递以及RC诱导的Ia抑制性中间神经元（IaINs）抑制作用的中枢效应。通过直接注入脊髓、注入腹根（L7）和/或注入腓肠肌（GS）肌肉来给予BTA。2. 将BTA直接注入脊髓导致RCs早期和晚期反应降低。3. 当将神经毒素注入GS肌肉时，在测试期（应用后33 - 46小时）RC活动未受影响。4. 注入腹根L7后长达10小时没有出现效应。5. 在局部肉毒中毒的动物中进行测试时，RC对IaINs的抑制作用在测试期保持完整。6. 根据目前的结果表明，在脊髓水平，肉毒杆菌毒素的中枢作用主要作用于运动神经元。

Hagenah R, Benecke R, Wiegand H

Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;299(3):267-72. doi: 10.1007/BF00500319.

The central action of botulinum toxin A (BTA) on the cholinergic transmission at Renshaw cells (RCs) and on the RC-induced inhibition of Ia inhibitory interneurones (IaINs) was studied in anaesthetized cats. BTA was administered by application directly into the spinal cord, injection into a ventral root (L7) and/or injection into the triceps surae (GS) muscle. 2. A direct application of BTA into the spinal cord led to a decrease of the early and the late response of RCs. 3. When the neurotoxin was injected into the GS muscle, the RC activity remained unaffected during the test period (33-46 h after application). 4. No effect appeared up to 10 h after an injection into the ventral root L7. 5. The RC-induced inhibition on IaINs, when tested in animals with local botulismus, remained intact during the test period. 6. From the present results it is suggested that on the spinal level the central action of botulinum toxin predominantly passes on the motoneurones.

在麻醉猫身上研究了A型肉毒杆菌毒素（BTA）对闰绍细胞（RCs）胆碱能传递以及RC诱导的Ia抑制性中间神经元（IaINs）抑制作用的中枢效应。通过直接注入脊髓、注入腹根（L7）和/或注入腓肠肌（GS）肌肉来给予BTA。2. 将BTA直接注入脊髓导致RCs早期和晚期反应降低。3. 当将神经毒素注入GS肌肉时，在测试期（应用后33 - 46小时）RC活动未受影响。4. 注入腹根L7后长达10小时没有出现效应。5. 在局部肉毒中毒的动物中进行测试时，RC对IaINs的抑制作用在测试期保持完整。6. 根据目前的结果表明，在脊髓水平，肉毒杆菌毒素的中枢作用主要作用于运动神经元。