肝损伤和异烟肼过敏。
Liver damage and isoniazid allergy.
作者信息
Assem E S, Ndoping N, Nicholson H, Wade J R
出版信息
Clin Exp Immunol. 1969 Oct;5(4):439-42.
Abstract
A patient with pulmonary tuberculosis developed jaundice and manifestations of generalized allergic reaction while receiving combined treatment with streptomycin, -aminosalicylate and isonicotinic acid hydrazide. Amongst various tests for allergy, the lymphocyte transformation test provided evidence of allergy to isonicotinic acid hydrazide. Follow-up suggested successful `desensitization', and plasma glutamic oxaloacetic transaminase showed only a temporary tendency to rise whilst desensitization was being carried out.
摘要
一名肺结核患者在接受链霉素、对氨基水杨酸和异烟肼联合治疗时出现黄疸及全身过敏反应表现。在各种过敏试验中，淋巴细胞转化试验证明对异烟肼过敏。随访显示“脱敏”成功，在进行脱敏治疗时，血浆谷草转氨酶仅呈现暂时升高的趋势。
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本文引用的文献
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Annu Rev Pharmacol. 1965;5:429-46. doi: 10.1146/annurev.pa.05.040165.002241.
2
STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN.过敏反应机制的研究。IX. 豚草花粉抗原引起人白细胞释放组胺
J Exp Med. 1964 Oct 1;120(4):507-30. doi: 10.1084/jem.120.4.507.
3
Fatal hepatic necrosis secondary to isoniazid therapy.异烟肼治疗继发的致命性肝坏死。
JAMA. 1961 Jun 10;176:877-9. doi: 10.1001/jama.1961.63040230013013b.
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Fatal hepatic necrosis associated with aminosalicylic acid; review of the literature and report of a case.与对氨基水杨酸相关的致命性肝坏死；文献综述及病例报告
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