通过体外被动致敏以及人肺和猴肺组胺释放检测青霉素及其他抗原过敏反应
Detection of allergy to penicillin and other antigens by in-vitro passive sensitization and histamine release from human and monkey lung.
作者信息
Assem E S, Schild H O
出版信息
Br Med J. 1968 Aug 3;3(5613):272-6. doi: 10.1136/bmj.3.5613.272.
Abstract
Preparations of chopped human and monkey lung were used to estimate the reaginic activity of serum from allergic patients. The lung preparation was passively sensitized by incubation with serum taken from the patients, and then challenged with the antigen responsible for the allergy. Measurement of the histamine released from the lung gave a quantitative assessment of the level of reaginic activity in the patient's serum.Tests were done on patients allergic to four natural antigens, including grass pollen, and to penicillin. Human lung proved more sensitive and possibly more specific than monkey lung in testing for natural allergies. The results of testing for penicillin allergies were less satisfactory, possibly because of the difficulty of reconstructing the appropriate antigen.
摘要
使用切碎的人肺和猴肺制剂来评估过敏患者血清中的反应素活性。通过与患者血清孵育使肺制剂被动致敏，然后用引起过敏的抗原进行激发。测量从肺中释放的组胺可对患者血清中反应素活性水平进行定量评估。对四种天然抗原（包括草花粉）过敏以及对青霉素过敏的患者进行了测试。在检测天然过敏方面，人肺比猴肺更敏感，可能也更具特异性。青霉素过敏测试的结果不太令人满意，可能是因为难以重建合适的抗原。
相似文献
1
Detection of allergy to penicillin and other antigens by in-vitro passive sensitization and histamine release from human and monkey lung.通过体外被动致敏以及人肺和猴肺组胺释放检测青霉素及其他抗原过敏反应
Br Med J. 1968 Aug 3;3(5613):272-6. doi: 10.1136/bmj.3.5613.272.
2
Testing for allergy.过敏测试
Br Med J. 1968 Aug 3;3(5613):262-3.
3
New in-vitro test for IgE-mediated hypersensitivity in man.用于人体IgE介导超敏反应的新型体外试验。
Br Med J. 1972 Jun 10;2(5814):623-4. doi: 10.1136/bmj.2.5814.623.
4
Studies on histamine release from leukocytes of penicillin-sensitive individuals.关于青霉素敏感个体白细胞组胺释放的研究。
Int Arch Allergy Appl Immunol. 1970;38(1):104-12. doi: 10.1159/000230263.
5
6
Skin-sensitizing antibodies in serum from patients with penicillin allergy studied by passive transfer to monkey skin and compared with results obtained on human skin (Prausnitz-Küstner technique).通过将血清被动转移至猴皮肤并与在人皮肤上获得的结果（普劳斯尼茨－屈斯特纳技术）进行比较，研究青霉素过敏患者血清中的皮肤致敏抗体。
Acta Allergol. 1969 Mar;24(1):57-72. doi: 10.1111/j.1398-9995.1969.tb03724.x.
7
Detection of penicillin allergy of the immediate type by radioimmunoassay of reagins (IgE) to penicilloyl conjugates.通过对青霉噻唑共轭物的反应素（IgE）进行放射免疫测定来检测速发型青霉素过敏。
Clin Allergy. 1971 Jun;1(2):171-7. doi: 10.1111/j.1365-2222.1971.tb03016.x.
8
In vitro histamine release from leukocytes in penicillin allergies.青霉素过敏患者白细胞的体外组胺释放
Acta Allergol. 1976 Dec;31(6):478-86. doi: 10.1111/j.1398-9995.1976.tb01498.x.
9
Serum IgE and other in vitro tests in drug allergy.药物过敏中的血清免疫球蛋白E及其他体外检测
Clin Allergy. 1972 Dec;2(4):325-34. doi: 10.1111/j.1365-2222.1972.tb01297.x.
10
[Allergy to betalactamins. Diagnosis in vivo and correlations with tests in vitro (lymphocyte transformation and specific IgE) (author's transl)].[对β-内酰胺类药物过敏。体内诊断及其与体外试验（淋巴细胞转化和特异性IgE）的相关性（作者译）]
Ann Dermatol Venereol. 1978 Jun-Jul;105(6-7):609-14.
引用本文的文献
1
A study of histamine release from human basophils and lung mast cells by products of lymphocyte stimulation.淋巴细胞刺激产物对人嗜碱性粒细胞和肺肥大细胞组胺释放的研究。
Agents Actions. 1983 Apr;13(2-3):222-30. doi: 10.1007/BF01967337.
2
Liver damage and isoniazid allergy.肝损伤和异烟肼过敏。
Clin Exp Immunol. 1969 Oct;5(4):439-42.
3
Human reagins: appraisal of the properties of the antibody of immediate-type hypersensitivity.人反应素：速发型超敏反应抗体特性的评估
Bacteriol Rev. 1972 Sep;36(3):311-60. doi: 10.1128/br.36.3.311-360.1972.
4
Treatment of anaphylactic shock.过敏性休克的治疗。
Br Med J. 1971 May 15;2(5758):398. doi: 10.1136/bmj.2.5758.398.
5
Histamine release from human lung by specific antisera.特异性抗血清诱导人肺组织释放组胺
Clin Exp Immunol. 1969 Sep;5(3):311-6.
6
7
Tests for penicillin allergy in man. I. Carrier effect on response to penicilloyl conjugates.人体青霉素过敏试验。I. 载体对青霉素酰缀合物反应的影响。
Immunology. 1974 Feb;26(2):425-40.
8
Inhibition of the release of mediators of immediate-type allergy in vivo and in vitro.体内和体外抑制速发型过敏介质的释放。
Proc R Soc Med. 1973 Dec;66(12):1191-8. doi: 10.1177/003591577306601221.
9
IgE-mediated hypersensitivity in human skin studied using a new in vitro method.采用一种新的体外方法研究人类皮肤中IgE介导的超敏反应。
Immunology. 1972 Aug;23(2):239-48.
10
New in-vitro test for IgE-mediated hypersensitivity in man.用于人体IgE介导超敏反应的新型体外试验。
Br Med J. 1972 Jun 10;2(5814):623-4. doi: 10.1136/bmj.2.5814.623.
本文引用的文献
1
Reactions of isolated human asthmatic lung and bronchial tissue to a specific antigen; histamine release and muscular contraction.离体人哮喘肺和支气管组织对特定抗原的反应；组胺释放和肌肉收缩。
Lancet. 1951 Sep 1;2(6679):376-82. doi: 10.1016/s0140-6736(51)91554-1.
2
A study of the mechanism of passive sensitization.被动致敏机制的研究。
J Physiol. 1960 Mar;150(3):546-64. doi: 10.1113/jphysiol.1960.sp006404.
3
STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN.过敏反应机制的研究。IX. 豚草花粉抗原引起人白细胞释放组胺
J Exp Med. 1964 Oct 1;120(4):507-30. doi: 10.1084/jem.120.4.507.
4
A quantitative study on the in vitro release of histamine from leukocytes of atopic persons.关于特应性个体白细胞中组胺体外释放的定量研究。
J Allergy. 1958 Sep;29(5):429-37. doi: 10.1016/0021-8707(58)90084-4.
5
Effect of temperature on the anaphylactic reaction.温度对过敏反应的影响。
J Physiol. 1957 Feb 15;135(2):320-38. doi: 10.1113/jphysiol.1957.sp005713.
6
Correlation of blood histamine release and skin test response to multiple antigens.血液组胺释放与针对多种抗原的皮肤试验反应的相关性。
J Allergy. 1955 Sep;26(5):385-93. doi: 10.1016/0021-8707(55)90029-0.
7
Improved automatic apparatus for pharmacological assays on isolated preparations.用于离体标本药理分析的改进型自动装置。
Br J Pharmacol Chemother. 1954 Mar;9(1):24-30. doi: 10.1111/j.1476-5381.1954.tb00811.x.
8
Techniques in tissue metabolism. I. A mechanical chopper.组织代谢技术。I. 一种机械切碎机。
Biochem J. 1953 Feb;53(3):412-20. doi: 10.1042/bj0530412.
9
Antigen induced release of histamine and SRS-A from human lung passively sensitized with reaginic serum.抗原诱导组胺和慢反应物质A从用反应素血清被动致敏的人肺中释放。
Nature. 1967 Oct 21;216(5112):283-4. doi: 10.1038/216283a0.
10
Depot grass-pollen injections in asthma: effect of repeated treatment on clinical response and measured bronchial sensitivity.长效缓释草花粉注射剂治疗哮喘：重复治疗对临床反应及测定的支气管敏感性的影响
Br Med J. 1967 Jan 7;1(5531):22-5. doi: 10.1136/bmj.1.5531.22.
Zotero 插件