ten Veen J H
Clin Exp Immunol. 1973 Nov;15(3):375-84.
Hydralazin, isoniazid, procainamide, α-methyldopa and chlorthalidone were given orally to mice of three inbred strains: C57/B1/6J, BALB/cJ and A/Jax. It was found that α-methyldopa and chlorthalidone induced smooth muscle (SMA) and skeletal muscle (SKMA) antibodies in all three strains. Hydralazin appeared to induce smooth muscle antibodies in A/Jax mice, but not in the other two strains. The smooth muscle antibodies correlated with one subtype of skeletal muscle antibodies. Lymphocellular infiltrates were found in the livers of a number of SMA-positive animals. No differences were noted between males and females. It is suggested that some drugs can induce changes in liver membrane antigen, resulting in an autoimmune response with formation of SMA and lymphocellular infiltration.
将肼屈嗪、异烟肼、普鲁卡因胺、α-甲基多巴和氯噻酮口服给予三个近交系小鼠：C57/B1/6J、BALB/cJ和A/Jax。发现α-甲基多巴和氯噻酮在所有三个品系中均诱导产生平滑肌（SMA）和骨骼肌（SKMA）抗体。肼屈嗪似乎在A/Jax小鼠中诱导产生平滑肌抗体，但在其他两个品系中未诱导产生。平滑肌抗体与骨骼肌抗体的一个亚型相关。在许多SMA阳性动物的肝脏中发现淋巴细胞浸润。未观察到雄性和雌性之间的差异。提示某些药物可诱导肝膜抗原发生变化，导致自身免疫反应，形成SMA和淋巴细胞浸润。
