慢性肾衰竭中的胃功能。维持性血液透析的影响。

Gastric function in chronic renal failure. Effects of maintenance haemodialysis.

作者信息

McConnell J B, Stewart W K, Thjodleifsson B, Wormsley K G

出版信息

Lancet. 1975 Dec 6;2(7945):1121-3. doi: 10.1016/s0140-6736(75)91007-7.

Abstract

40 patients with chronic renal failure have been studied in order to determine why some patients with azotaemia have previously been reported to secrete abnormally large amounts of acid and some to secrete very little. 15 of the 40 patients were undergoing regular haemodialysis, while the remaining 25 patients had not been so treated. 10 of the 25 non-dialysed patients had much-impaired capacity to secrete acid. The impaired gastric secretory capacity was corrected and became abnormally great after some months of regular haemodialysis in 4 patients. Regular haemodialysis, by removing factors responsible for the gastric mucosal damage, permits manifestations of an underlying gastric hypersecretory state.

摘要

为了确定为什么先前有报道称一些氮质血症患者分泌异常大量的酸，而另一些患者分泌极少，对40例慢性肾衰竭患者进行了研究。40例患者中有15例正在接受定期血液透析，其余25例患者未接受过此类治疗。25例未透析患者中有10例分泌酸的能力严重受损。4例患者在进行数月的定期血液透析后，受损的胃分泌能力得到纠正并变得异常强大。定期血液透析通过去除导致胃黏膜损伤的因素，使潜在的胃分泌过多状态得以显现。