Pietra G G, Szidon J P, Leventhal M M, Fishman A P
Science. 1969 Dec 26;166(3913):1643-6. doi: 10.1126/science.166.3913.1643.
Stroma-free hemoglobin is an electron-opaque molecule useful as a tracer for the ultrastructural stuty of pulmonary capillary permeability. After this tracer was infused into the isolated pulmonary lobe of the dog, the endothelial junctions of the capillaries, as revealed by electron microscopy, act like distensible pores, thus allowing the tracer to escape when the pulmonary artery pressure was raised above 50 millimeters of mercury.
无基质血红蛋白是一种电子致密分子，可用作肺毛细血管通透性超微结构研究的示踪剂。将这种示踪剂注入犬的离体肺叶后，电子显微镜显示，毛细血管的内皮连接就像可扩张的孔隙，因此当肺动脉压升高到50毫米汞柱以上时，示踪剂就会逸出。
