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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Biochem J. 1970 Apr;117(2):267-70. doi: 10.1042/bj1170267.

[4-(14)C]Oestradiol was administered to seven male, seven female and two castrated male cats as a single intravenous injection. Bile and urine were collected for 6h. 2. The radioactivity was excreted mainly in the bile of all animals (53-60%); only approx. 1% of the dose appeared in the urine. 3. Bile and urine samples were hydrolysed successively by beta-glucuronidase, cold acid and hot acid. There were significant differences (P<0.005) between the percentage of the dose present in the bile fractions hydrolysed by beta-glucuronidase (male, 9.0+/-1.7%; female, 18.6+/-1.45%) and by cold acid (male, 18.9+/-1.44%; female 12.1+/-1.02%). The excretion of radioactivity in these fractions by the castrated male cats was closer to that of female cats. 4. Approx. 20-27% of the dose could not be extracted from aqueous solution (pH10.5) by ethyl acetate-ether after hydrolysis.

以单次静脉注射的方式，给7只雄性猫、7只雌性猫和2只去势雄性猫注射了[4-(14)C]雌二醇。收集胆汁和尿液6小时。2. 放射性物质主要通过所有动物的胆汁排出（53 - 60%）；只有约1%的剂量出现在尿液中。3. 胆汁和尿液样本先后用β-葡萄糖醛酸酶、冷酸和热酸进行水解。经β-葡萄糖醛酸酶水解的胆汁组分中剂量百分比（雄性，9.0±1.7%；雌性，18.6±1.45%）与经冷酸水解的（雄性，18.9±1.44%；雌性，12.1±1.02%）之间存在显著差异（P<0.005）。去势雄性猫在这些组分中的放射性物质排泄情况更接近雌性猫。4. 水解后，约20 - 27%的剂量不能用乙酸乙酯 - 乙醚从pH10.5的水溶液中萃取出来。

Biochem J. 1970 Apr;117(2):267-70. doi: 10.1042/bj1170267.

[4-(14)C]Oestradiol was administered to seven male, seven female and two castrated male cats as a single intravenous injection. Bile and urine were collected for 6h. 2. The radioactivity was excreted mainly in the bile of all animals (53-60%); only approx. 1% of the dose appeared in the urine. 3. Bile and urine samples were hydrolysed successively by beta-glucuronidase, cold acid and hot acid. There were significant differences (P<0.005) between the percentage of the dose present in the bile fractions hydrolysed by beta-glucuronidase (male, 9.0+/-1.7%; female, 18.6+/-1.45%) and by cold acid (male, 18.9+/-1.44%; female 12.1+/-1.02%). The excretion of radioactivity in these fractions by the castrated male cats was closer to that of female cats. 4. Approx. 20-27% of the dose could not be extracted from aqueous solution (pH10.5) by ethyl acetate-ether after hydrolysis.

以单次静脉注射的方式，给7只雄性猫、7只雌性猫和2只去势雄性猫注射了[4-(14)C]雌二醇。收集胆汁和尿液6小时。2. 放射性物质主要通过所有动物的胆汁排出（53 - 60%）；只有约1%的剂量出现在尿液中。3. 胆汁和尿液样本先后用β-葡萄糖醛酸酶、冷酸和热酸进行水解。经β-葡萄糖醛酸酶水解的胆汁组分中剂量百分比（雄性，9.0±1.7%；雌性，18.6±1.45%）与经冷酸水解的（雄性，18.9±1.44%；雌性，12.1±1.02%）之间存在显著差异（P<0.005）。去势雄性猫在这些组分中的放射性物质排泄情况更接近雌性猫。4. 水解后，约20 - 27%的剂量不能用乙酸乙酯 - 乙醚从pH10.5的水溶液中萃取出来。