Lloyd H M, Jacobi J M, Cooke R A
J Clin Pathol. 1979 Dec;32(12):1278-81. doi: 10.1136/jcp.32.12.1278.
Nuclear diameter was measured in 55 parathyroid chief-cell adenomas to determine its value in histological diagnosis and to assess its relationship to other features of primary hyperparathyroidism. Mean nuclear diameter for the whole group of adenomas was significantly greater than that for the accompanying normal glands. Mean nuclear diameter in individual adenomas was significantly greater than that in the accompanying normal gland in 27 out of 34 cases. Nuclear diameter was correlated with tumour weight and with plasma calcium but was not correlated with duration of history. It was significantly greater in the group of patients with overt bone disease than in those with kidney stones and in those with neither kidney stones nor overt bone disease. Assessment of nuclear diameter is of value in histological diagnosis of parathyroid adenoma. The rate of growth of the adenoma may be a factor determining nuclear diameter.
对55例甲状旁腺主细胞腺瘤进行了核直径测量,以确定其在组织学诊断中的价值,并评估其与原发性甲状旁腺功能亢进其他特征的关系。整个腺瘤组的平均核直径显著大于伴行的正常腺体。在34例中的27例中,单个腺瘤的平均核直径显著大于伴行的正常腺体。核直径与肿瘤重量和血浆钙相关,但与病程无关。有明显骨病的患者组的核直径显著大于有肾结石的患者组以及既无肾结石也无明显骨病的患者组。核直径评估在甲状旁腺腺瘤的组织学诊断中有价值。腺瘤的生长速率可能是决定核直径的一个因素。