Macfarlane J T, Anjorin F I, Cleland P G, Hassan-King M, Tor-Agbidye S, Wali S S, Weir W R, Whittle H C, Yahaya H N, Greenwood B M
Trans R Soc Trop Med Hyg. 1979;73(6):693-7. doi: 10.1016/0035-9203(79)90023-3.
A single injection of a long-acting preparation of penicillin (Triplopen) was compared with a five-day course of crystalline and procaine penicillin in the treatment of meningococcal meningitis. The clinical response of patients treated with Triplopen was very similar to that of patients treated with crystalline penicillin and much more convenient to administer. However, four patients treated with Triplopen had a positive CSF culture 48 or 72 hours after their injection. One injection of Triplopen cannot, therefore, be recommended as an entirely safe form of treatment for meningococcal meningitis unless patients can be carefully followed.
将长效青霉素制剂（三联青霉素）单次注射与结晶青霉素和普鲁卡因青霉素的五日疗程用于治疗脑膜炎球菌性脑膜炎进行了比较。接受三联青霉素治疗的患者的临床反应与接受结晶青霉素治疗的患者非常相似，而且给药更方便。然而，接受三联青霉素治疗的4名患者在注射后48或72小时脑脊液培养呈阳性。因此，除非能对患者进行仔细随访，否则不能推荐单次注射三联青霉素作为脑膜炎球菌性脑膜炎的完全安全的治疗方式。
