Wali S S, Macfarlane J T, Weir W R, Cleland P G, Ball P A, Hassan-King M, Whittle H C, Greenwood B M
Trans R Soc Trop Med Hyg. 1979;73(6):698-702. doi: 10.1016/0035-9203(79)90024-5.
A single injection of a long-acting oily preparation of chloramphenicol (Tifomycine) was compared with a five-day course of crystalline and procaine penicillin in the treatment of 131 adult patients with meningococcal meningitis. The clinical response to treatment was similar in the two groups of patients. Serial lumbar punctures showed a parallel fall in CSF cell count, protein and lactate and all posttreatment cultures were sterile. Single injection chloramphenicol treatment was cheaper and much easier to administer than penicillin. Long-acting chloramphenicol is thus an effective form of treatment for meningococcal meningitis and is likely to prove of particular value in the management of epidemics in areas with limited medical resources.
将长效油性氯霉素制剂（替莫西芬）单次注射与结晶青霉素和普鲁卡因青霉素五日疗程，用于治疗131例成人脑膜炎球菌性脑膜炎患者，并进行比较。两组患者的临床治疗反应相似。连续腰椎穿刺显示脑脊液细胞计数、蛋白质和乳酸水平平行下降，且所有治疗后的培养均无菌。单次注射氯霉素治疗比青霉素更便宜且更易于给药。因此，长效氯霉素是治疗脑膜炎球菌性脑膜炎的一种有效形式，并且可能在医疗资源有限地区的疫情管理中证明具有特殊价值。
