Petrov L, Karachiviev D, Bredy-Dobreva G
Acta Physiol Pharmacol Bulg. 1979;5(3):19-26.
Acute experiments on cats are carried out to study the effect on the value of the pressor and depressor responses of the systemic arterial pressure (SAP) of the rise in the central venous pressure (CVP), occurring upon the administration of some hyper- and hypotensive agents. The responses of SAP to intravenous injection of different doses of noradrenaline and acetylcholine are determined at rest, after vagotomy, during intravenous infusion of dextrane solution and after vagotomy during infusion. It is shown that when the hypertensive agent causes a rise in CVP in addition to its pressor effect, the pressor response is subjected both to carotid and to aortic buffering as a result of the increased SAP, as well as to cardiopulmonary buffering due to the rise in CVP. In the case of the hypotensive agent the rise in CVP does not influence the value of the depressor SAP response, since the changes in the activation of the cardiopulmonary and arterial baroreceptors are in different directions. Evidence is presented in support of the assumption that the cardiopulmonary inhibition is transmitted along extravagal afferent ways in addition to being transmitted along the vagal nerves.
对猫进行急性实验，以研究某些升压和降压药物给药后，中心静脉压（CVP）升高对体循环动脉压（SAP）的升压和降压反应值的影响。在静息状态、迷走神经切断术后、静脉输注右旋糖酐溶液期间以及输注期间迷走神经切断术后，测定SAP对静脉注射不同剂量去甲肾上腺素和乙酰胆碱的反应。结果表明，当升压药物除了其升压作用外还导致CVP升高时，由于SAP升高，升压反应会受到颈动脉和主动脉缓冲的影响，同时也会因CVP升高而受到心肺缓冲的影响。对于降压药物，CVP升高并不影响SAP降压反应的值，因为心肺和动脉压力感受器激活的变化方向不同。有证据支持这样的假设，即心肺抑制除了通过迷走神经传导外，还通过迷走神经外传入途径传导。
