脂质体包裹的皮质类固醇。II. 对实验性关节炎的治疗活性
Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis.
作者信息
Phillips N C, Thomas D P, Knight C G, Dingle J T
出版信息
Ann Rheum Dis. 1979 Dec;38(6):553-7. doi: 10.1136/ard.38.6.553.
Abstract
The anti-inflammatory activity of liposomes containing cortisol palmitate was determined in experimental acute arthritis in the rabbit knee by measuring joint temperature and diameter. The therapeutic activity of the liposome preparation was dose-dependent for both these parameters of inflammation. Liposomal corticosteroid therapy was effective also in decreasing the joint temperature of an acute inflammatory 'flare' superimposed on an underlying chronic arthritis. Phosphatidic acid was necessary for expression of full anti-inflammatory activity of the liposome preparation.
摘要
通过测量关节温度和直径，在兔膝关节实验性急性关节炎中测定了含有棕榈酸皮质醇的脂质体的抗炎活性。对于炎症的这两个参数，脂质体制剂的治疗活性呈剂量依赖性。脂质体皮质类固醇疗法在降低叠加于潜在慢性关节炎之上的急性炎症“发作”的关节温度方面也有效。磷脂酸对于脂质体制剂充分发挥抗炎活性是必需的。
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