一种改良抗炎类固醇的脂质体保留
Liposomal retention of a modified anti-inflammatory steroid.
作者信息
Shaw I H, Knight C G, Dingle J T
出版信息
Biochem J. 1976 Aug 15;158(2):473-6. doi: 10.1042/bj1580473.
Abstract
In studies with synthetic lecithins, dipalmitoylphosphatidylcholine was found to be the preferred form for liposomal retention of cortisol esters at 37 degrees C. Cortisol palmitate was retained longer than cortisol octanoate, whereas unesterified cortisol escaped readily from liposomes. Such a liposome composition may allow the controlled release of modified anti-inflammatory agents, particularly when used for intra-articular administration.
摘要
在使用合成卵磷脂的研究中，发现二棕榈酰磷脂酰胆碱是在37摄氏度时用于脂质体保留皮质醇酯的首选形式。棕榈酸皮质醇比辛酸皮质醇保留的时间更长，而未酯化的皮质醇很容易从脂质体中逸出。这种脂质体组合物可以使修饰的抗炎剂得到控释，特别是当用于关节内给药时。
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