静脉注射两种不同菌株的微小棒状杆菌对小鼠的影响。
Effects of intravenous injection of two different strains of Corynebacterium parvum in the mouse.
作者信息
Sadler T E, Jones P D, Castro J E, Lampert I A
出版信息
Br J Exp Pathol. 1979 Dec;60(6):627-31.
Abstract
A strain of C. parvum, CN6134, known to have antitumour activity, caused thrombosis in the sites where the organism is phagocytosed. It bound to macrophages in vitro and activated the alternate pathway of complement. A strain of C. parvum, CN5888, which fails to show antitumour activity, did not show thrombosis. It did not bind to macrophages or activate guinea-pig complement. It did, however, cause marrow infarction which seems to result from a diminished clearance of the organism from the circulation.
摘要
已知具有抗肿瘤活性的微小隐孢子虫菌株CN6134，在该生物体被吞噬的部位引发血栓形成。它在体外与巨噬细胞结合并激活补体替代途径。未能显示抗肿瘤活性的微小隐孢子虫菌株CN5888未出现血栓形成。它不与巨噬细胞结合或激活豚鼠补体。然而，它确实导致了骨髓梗死，这似乎是由于该生物体从循环中的清除减少所致。
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