Jones P D, Sadler T E, Castro J E
Br J Cancer. 1977 Dec;36(6):777-82. doi: 10.1038/bjc.1977.261.
The level of peripheral blood platelets was determined after i.v. injection of Corynebacterium parvum in normal C57BL mice and in those bearing the Lewis lung carcinoma. Twenty minutes after injection of a formalin-killed active strain (CN6134, (CN6134, which inhibited tumour metastases) or a killed inactive strain (CN 5888, which did not inhibit metastases) the number of circulating blood platelets was reduced by 50%. The level of platelets returned to control values by 8 h after the active, and by approximately 3 days after the inactive strain. The active strain alone caused a second and prolonged fall in platelet numbers, from approximately 16 h to 21 days after injection. Heparin given 3 X weekly to these mice restored the platelet count to normal values by 10 days after injection of active-strain C. parvum. The level of platelets in tumour-bearing mice was essentially similar to that in normal mice. Possible causes of the thrombocytopenia and the significance of platelets in metastasis are discussed.
在正常C57BL小鼠和携带Lewis肺癌的小鼠静脉注射短小棒状杆菌后，测定外周血血小板水平。注射福尔马林灭活的活性菌株（CN6134，可抑制肿瘤转移）或灭活的非活性菌株（CN 5888，不抑制转移）20分钟后，循环血小板数量减少50%。活性菌株注射后8小时，非活性菌株注射后约3天，血小板水平恢复到对照值。单独的活性菌株导致血小板数量在注射后约16小时至21天出现第二次且持续时间较长的下降。每周给这些小鼠注射3次肝素，在注射活性菌株短小棒状杆菌后10天，血小板计数恢复到正常值。荷瘤小鼠的血小板水平与正常小鼠基本相似。讨论了血小板减少的可能原因以及血小板在转移中的意义。
