Konsmantinova M S
Biull Eksp Biol Med. 1979 Nov;88(11):518-20.
6-hydroxydopamine (6-HD), producing specific destruction of noradrenergic (NA) terminals, was used to study the role of NA innervation in the production of peptide neurohormones by the supraoptic nucleus (SON) cells. Seven days after intraventricular administration of 6-HD in a dose of 250 micrograms the fluorescence intensity of NA terminals in SON area was highly decreased and morphological pictures, reflecting the activation of hormone production in SON cells, were observed. According to the data obtained NA innervation is likely to inhibit the peptide neurohormone synthesis by SON cells and to regulate the transport and release of peptide neurohormones from the posterior pituitary into general circulation.
6-羟基多巴胺（6-HD）可特异性破坏去甲肾上腺素能（NA）终末，被用于研究NA神经支配在视上核（SON）细胞产生肽类神经激素过程中的作用。以250微克的剂量脑室内注射6-HD 7天后，SON区域内NA终末的荧光强度显著降低，并且观察到了反映SON细胞激素产生激活的形态学图像。根据所获得的数据，NA神经支配可能抑制SON细胞的肽类神经激素合成，并调节肽类神经激素从垂体后叶向全身循环的转运和释放。
