易中风自发性高血压大鼠动脉壁结缔组织代谢的生化改变

Biochemical alterations of connective tissue metabolism in the arterial walls of stroke-prone spontaneously hypertensive rats.

Ooshima A, Yamori Y, Ohta K, Nara Y, Horie R

Clin Sci (Lond). 1979 Dec;57 Suppl 5:35s-37s. doi: 10.1042/cs057035s.

Abstract

The chemical characteristics of the vascular connective tissue components were determined in stroke-prone (SP), stroke-resistant (SR) spontaneously hypertensive (SH) rats and normotensive Wistar-Kyoto (WK) rats. 2. The ratio of hydroxylysine to hydroxylsine plus lysine in the vascular collagen was increased in 6-month-old SP-SH rats and SR-SH rats as compared with WK rats. 3. An age-related increase in uronic acid and hexose content of the aorta was noted in SP-SH, SR-SH and WK rats. However, the increase was more prominent in SH rats, especially SP-SH rats at the stages examined (11 weeks and over 8 months of age). 4. The ratio of galactosyl-hydroxylysine to glucosyl-galactosyl-hydroxylysine in the aortic collagen was decreased in 6-month-old SH rats, especially SP-SH rats as compared with WK rats. 5. A relative increase in beta and gamma components in aortic collagen was noted in 6-month-old SP-SH rats when compared with SR-SH rats. 6. The increased content of uronic acid and hexose and the structural changes of vascular collagen as demonstrated in SP-SH rats might be related to the fragility of the arterial wall and/or to the pathogenesis of stroke-proneness.

摘要

对易中风（SP）、抗中风（SR）的自发性高血压（SH）大鼠以及正常血压的Wistar-Kyoto（WK）大鼠的血管结缔组织成分的化学特性进行了测定。2. 与WK大鼠相比，6月龄的SP-SH大鼠和SR-SH大鼠血管胶原蛋白中羟赖氨酸与羟赖氨酸加赖氨酸的比例有所增加。3. 在SP-SH、SR-SH和WK大鼠中均观察到主动脉中糖醛酸和己糖含量随年龄增长而增加。然而，这种增加在SH大鼠中更为显著，尤其是在所检查阶段（11周龄及8月龄以上）的SP-SH大鼠。4. 与WK大鼠相比，6月龄的SH大鼠，尤其是SP-SH大鼠主动脉胶原蛋白中半乳糖基羟赖氨酸与葡萄糖基半乳糖基羟赖氨酸的比例降低。5. 与SR-SH大鼠相比，6月龄的SP-SH大鼠主动脉胶原蛋白中的β和γ成分相对增加。6. SP-SH大鼠中糖醛酸和己糖含量的增加以及血管胶原蛋白的结构变化可能与动脉壁的脆弱性和/或易中风的发病机制有关。