Goodfellow R M
Curr Med Res Opin. 1979;6(5):371-5. doi: 10.1185/03007997909109453.
A multi-centre, open study was carried out in 140 hypertensive patients to investigate the hypotensive effect of 2 tablets of a fixed combination of 100 mg metoprolol plus 12.5 mg hydrochlorothiazide when taken either once-daily or twice-daily, each for 4 weeks. Blood pressure and pulse rate measurements were taken at rest, during and after exercise, on entry and at the end of each treatment period. The mean resting blood pressures were 168/108 mmHg, 151/98 mmHg and 150/96 mmHg at pre-trial, after the twice-daily dosage period and after the once-daily dosage period, respectively. The corresponding figures for exercise blood pressure were 191/115 mmHg, 176/105 mmHg, and 174/102 mmHg. Few side-effects were reported. It is concluded that once-daily dosing with this combination product is an effective and well-tolerated treatment for mild to moderate hypertension throughout the full 24-hour period.
对140例高血压患者进行了一项多中心开放性研究，以调查100毫克美托洛尔与12.5毫克氢氯噻嗪固定复方片剂每日服用一次或两次、各服用4周时的降压效果。在入组时以及每个治疗期结束时，于静息状态、运动期间及运动后测量血压和脉搏率。试验前、每日服用两次剂量期结束后及每日服用一次剂量期结束后的平均静息血压分别为168/108 mmHg、151/98 mmHg和150/96 mmHg。运动血压的相应数值分别为191/115 mmHg、176/105 mmHg和174/102 mmHg。报告的副作用很少。结论是，每日一次服用该复方产品是治疗轻至中度高血压在整个24小时期间有效的且耐受性良好的疗法。
