Goodfellow R M, Westberg B
Curr Med Res Opin. 1981;7(8):536-42. doi: 10.1185/03007998109112370.
A post-marketing surveillance programme was carried out in general practice to evaluate the efficacy and tolerability of a fixed-dose combination of 100 mg metoprolol and 12.5 mg hydrochlorothiazide in the treatment of mild to moderate hypertension, with particular reference to elderly patients. Patients received a single daily dose over a period of 3 months. The results of the analysis of data from 1446 patients showed that, although the initial blood pressure was higher in the elderly, both the systolic and diastolic pressures were reduced by the same degree after 3-months' treatment, regardless of age. The incidence of side-effects was similar in all age groups, although a higher proportion of these side-effects led to treatment withdrawal in the elderly, possibly reflecting an increasing overall intolerance to drugs with age. The results suggest that treatment with the metoprolol/hydrochlorothiazide combination is effective and well tolerated in the majority of hypertensive patients, irrespective of age or previous antihypertensive therapy.
在普通医疗实践中开展了一项上市后监测项目，以评估100毫克美托洛尔与12.5毫克氢氯噻嗪固定剂量复方制剂治疗轻至中度高血压的疗效和耐受性，尤其针对老年患者。患者在3个月期间每日服用单一剂量。对1446例患者数据的分析结果显示，尽管老年患者的初始血压较高，但经过3个月治疗后，收缩压和舒张压下降程度相同，与年龄无关。所有年龄组的副作用发生率相似，尽管这些副作用导致老年患者停药的比例较高，这可能反映出随着年龄增长对药物的总体耐受性增加。结果表明，无论年龄或既往抗高血压治疗情况如何，美托洛尔/氢氯噻嗪复方制剂治疗对大多数高血压患者有效且耐受性良好。
