Beaugé F, Clément M, Renaud G, Nordmann R, Nordmann J
Arch Int Physiol Biochim. 1975 Aug;83(3):573-91. doi: 10.3109/13813457509071401.
Isopropanol administration (3 g/kg, p.o.) determines in the rat liver an inhibition of fatty acid oxidation, an enhancement of fatty acid esterification into triacylglycerols as well as an inhibition of lipoprotein secretion which appears to be related to alterations in hepatic phospholipids and which differentiates isopropanol from ethanol induced fatty liver. Disturbances in peripheral lipolysis following isopropanol administration are found only in mature rats and are not necessary to the fatty liver induction.
经口给予异丙醇（3克/千克）可导致大鼠肝脏中脂肪酸氧化受到抑制，脂肪酸酯化生成三酰甘油增加，以及脂蛋白分泌受到抑制，这种抑制似乎与肝脏磷脂的改变有关，这也使得异丙醇诱导的脂肪肝与乙醇诱导的脂肪肝有所不同。给予异丙醇后外周脂肪分解的紊乱仅在成年大鼠中发现，且并非诱导脂肪肝所必需。
