Beaugé F, Clément M, Nordmann J, Nordmann R
Arch Int Physiol Biochim. 1977 Dec;85(5):931-40. doi: 10.3109/13813457709053293.
Isopropanol and acetone administered to rats in conditions leading to a similar blood acetone level differ markedly in their effects on lipid metabolism. Isopropanol administration determines a fatty liver, which is mainly related to a defect in hepatic lipoprotein synthesis. Acetone administration gives only raise to a slight increase in the liver triacylglycerol level. It does not alter the [1-14C] palmitate, [1-14C] glycerol or [U-14C] leucine incorporation into blood lipoproteins. Acetone does thus not appear to play a preminent role in the isopropanol induced fatty liver which seems to be related mainly to a direct action of the alcohol itself.
在使大鼠血液中丙酮水平相似的条件下给予异丙醇和丙酮，它们对脂质代谢的影响显著不同。给予异丙醇会导致脂肪肝，这主要与肝脏脂蛋白合成缺陷有关。给予丙酮只会使肝脏三酰甘油水平略有升高。它不会改变[1-¹⁴C]棕榈酸、[1-¹⁴C]甘油或[U-¹⁴C]亮氨酸掺入血液脂蛋白的情况。因此，丙酮似乎在异丙醇诱导的脂肪肝中不发挥主要作用，这种脂肪肝似乎主要与酒精本身的直接作用有关。
